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Partial neuromuscular block impairs arytenoid abduction during hypercarbic challenge in anesthetized dogs
- Source :
- Veterinary Anaesthesia and Analgesia. 44:1049-1056
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objective To evaluate the effect of two levels of partial neuromuscular block (NMB) on arytenoid abduction, tidal volume (VT) and peak inspiratory flow (PIF) in response to a hypercarbic challenge in anesthetized dogs. Study design Prospective laboratory study. Animals Eleven healthy male Beagle dogs aged 3–5 years. Methods Dogs were anesthetized with propofol and dexmedetomidine infusions. The rima glottidis was observed via an endoscope placed through a laryngeal mask airway. Atracurium infusion was titrated to obtain two levels of partial NMB. The normalized glottal gap area (NGGA; glottal gap area normalized to height squared of rima glottidis) at peak inspiration during a hypercarbic challenge (10% CO2 inspired for 1 minute) was measured at baseline, during mild [train-of-four (TOF) ratio 0.4–0.6] and shallow (TOF ratio 0.7–0.9) NMB, and 30 minutes after spontaneous recovery from NMB. The VT and PIF were measured at the same time points and compared using anova for repeated measures and Tukey’s post hoc tests. Results The NGGA and VT were significantly lower than baseline during both levels of partial NMB with no difference between mild and shallow NMB (p Conclusions and clinical relevance The NGGA and VT at peak inspiration in response to a hypercarbic challenge were reduced during partial NMB block, with decreased abduction of the arytenoid cartilages. This dysfunction was present even at shallow levels of NMB.
- Subjects :
- Male
040301 veterinary sciences
Anesthesia, General
Beagle
Hypercapnia
0403 veterinary science
03 medical and health sciences
Dogs
0302 clinical medicine
Laryngeal mask airway
030202 anesthesiology
medicine
Animals
Dexmedetomidine
Peak flow meter
Propofol
Tidal volume
measurement_unit
Laryngoscopy
General Veterinary
business.industry
Repeated measures design
04 agricultural and veterinary sciences
Carbon Dioxide
medicine.anatomical_structure
Rima glottidis
Anesthesia
measurement_unit.measuring_instrument
Anesthesia, Intravenous
Neuromuscular Blockade
Laryngeal Muscles
business
medicine.drug
Subjects
Details
- ISSN :
- 14672987
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Veterinary Anaesthesia and Analgesia
- Accession number :
- edsair.doi.dedup.....ab776c0047b0cfe2a2383964e6307cb5