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Portland Intensive Insulin Therapy During Living Donor Liver Transplantation: Association with Postreperfusion Hyperglycemia and Clinical Outcomes
- Source :
- Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
- Publication Year :
- 2018
-
Abstract
- Many liver transplant recipients experience intraoperative hyperglycemia after graft reperfusion. Accordingly, we introduced the Portland intensive insulin therapy (PoIIT) in our practice to better control blood glucose concentration (BGC). We evaluated the effects of PoIIT by comparing with our conventional insulin therapy (CoIT). Of 128 patients who underwent living donor liver transplantation (LDLT) during the phaseout period of CoIT, 89 were treated with the PoIIT and 39 were treated with CoIT. The primary outcome was hyperglycemia (BGC > 180 mg/dL) during the intraoperative postreperfusion phase. The secondary outcomes were postoperative complications such as infection. The incidence of hyperglycemia (22.5% vs. 53.8%, p = 0.001) and prolonged hyperglycemia for >2 hours (7.9% vs. 30.8%, p = 0.002) was significantly lower in PoIIT group than in CoIT group. A mixed linear model further demonstrated that repeatedly measured BGCs were lower in PoIIT group (p
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
lcsh:Medicine
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
Clinical Protocols
Risk Factors
Diabetes mellitus
Internal medicine
Mixed linear model
medicine
Living Donors
Humans
Insulin
030212 general & internal medicine
Prospective Studies
Prospective cohort study
lcsh:Science
Intraoperative Complications
Retrospective Studies
Mechanical ventilation
Multidisciplinary
Intraoperative Care
business.industry
Incidence (epidemiology)
lcsh:R
Retrospective cohort study
Middle Aged
medicine.disease
Liver Transplantation
Treatment Outcome
Hyperglycemia
Reperfusion
030211 gastroenterology & hepatology
lcsh:Q
Female
Living donor liver transplantation
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....ab67b6253549d672daa57625efcdbb21