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Pre-operative evaluation of circulating KL-6 levels as a biomarker for epithelial ovarian carcinoma and its correlation with tumor MUC1 expression
- Source :
- Oncology Letters
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- Krebs von den Lungen-6 (KL-6), a mucinous sialylated sugar chain on human mucin-1 glycoprotein (MUC1), is a diagnostic marker for interstitial lung diseases. Furthermore, elevated serum KL-6 levels have been observed in certain malignant tumor types of epithelial origin. The expression of MUC1 has been observed in patients with epithelial ovarian cancer (EOC) and is considered a potential therapeutic target. In the present study, KL-6 serum levels were investigated in patients clinically suspected of having malignant ovarian tumors. A total of 219 patients were enrolled in the study, which analyzed their serum KL-6 levels in addition to tumor expression of MUC1 using immunohistochemistry. High serum KL-6 levels were predominantly observed in patients with EOC, and did not occur in patients with benign or borderline tumors. The level of serum KL-6 was highly correlated with tumor stage, grade and histological type, and demonstrated superior sensitivity for the detection of ovarian cancer compared with that of serum cancer antigen 125. High serum KL-6 was significantly associated with shorter progression-free survival. In addition, tumor MUC1 expression status was significantly correlated with serum KL-6 levels. These data suggest that serum KL-6 may be a useful, non-invasive biomarker surrogate for tumor MUC1 expression in future clinical trials of MUC1-targeted therapy.
- Subjects :
- 0301 basic medicine
Cancer Research
Biology
03 medical and health sciences
0302 clinical medicine
medicine
MUC1
Oncogene
diagnostic marker
Cancer
Articles
Cell cycle
medicine.disease
Molecular medicine
Krebs von den Lungen-6
human mucin-1 glycoprotein
030104 developmental biology
ovarian cancer
Oncology
030220 oncology & carcinogenesis
serum biomarker
Cancer research
Biomarker (medicine)
Immunohistochemistry
Ovarian cancer
Corrigendum
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....ab66b0f37e17650b91c8f0cafb054cfe