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Comparison of Clinical Features between Immune-Related Sclerosing Cholangitis and Hepatitis
- Source :
- Investigational New Drugs
- Publication Year :
- 2021
- Publisher :
- Research Square Platform LLC, 2021.
-
Abstract
- Background Immune-related hepatotoxicity is often regarded as immune-related hepatitis (irHepatitis) despite including immune-related sclerosing cholangitis (irSC). This study examined the clinical differences between irSC and irHepatitis.Methods A single-center retrospective study of 530 consecutive patients who received immunotherapy between August 2014 and April 2020 was performed. IrSC and irHepatitis were respectively defined as the radiological presence and absence of bile duct dilation and wall thickness.Results Forty-one patients (7.7%) developed immune-related hepatotoxicity. A CT scan was performed on 12 patients, including 11 of 12 with ≥grade 3 aminotransferase elevations. IrSC and irHepatitis were diagnosed in 4 (0.8%) and 8 (1.5%) patients, respectively. All the irSC patients had been treated with anti-PD-1. IrHepatitis was more common among patients receiving anti-CTLA-4 than among those receiving anti-PD-1/PD-L1 inhibitors (14%, 7/50 vs. 0.2%, 1/480, P Conclusions IrSC and irHepatitis have different characteristics in the class of immune checkpoint inhibitor and onset pattern. Radiological examination for the diagnosis of irSC should be considered for patients with ≥grade 2 ALP elevation resulting in a cholestatic pattern. (Registration number J2020-36, Date of registration June 3, 2020)
- Subjects :
- Male
medicine.medical_specialty
Drug-induced liver injury
medicine.medical_treatment
Cholangitis, Sclerosing
Short Report
Secondary sclerosing cholangitis
Gastroenterology
Hepatitis
03 medical and health sciences
0302 clinical medicine
Immune system
Immune-related adverse events
Internal medicine
Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Medicine
Humans
Pharmacology (medical)
Immune Checkpoint Inhibitors
Transaminases
Aged
Retrospective Studies
Pharmacology
business.industry
Bile duct
Retrospective cohort study
Immunotherapy
Regulatory T cells
Radiological examination
Middle Aged
medicine.disease
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Alkaline phosphatase
030211 gastroenterology & hepatology
Female
business
Tomography, X-Ray Computed
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Investigational New Drugs
- Accession number :
- edsair.doi.dedup.....ab541e14a9d8045ee3938739fb9f60bf