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Disentangling the varying associations between systolic blood pressure and health outcomes in the very old
- Source :
- Journal of Hypertension, 40(9), 1786-1794. LIPPINCOTT WILLIAMS & WILKINS
- Publication Year :
- 2022
- Publisher :
- LIPPINCOTT WILLIAMS & WILKINS, 2022.
-
Abstract
- Objectives: While randomized controlled trials have proven the benefits of blood pressure (BP) lowering in participating octogenarians, population-based observational studies suggest an association between low systolic blood pressure (SBP) and faster overall decline. This study investigates the effects of BP-lowering treatment, a history of cardiovascular diseases (CVD), and cognitive and physical fitness on the associations between SBP and health outcomes in the very old. Methods: Five cohorts from the Towards Understanding Longitudinal International older People Studies (TULIPS) consortium were included in a two-step individual participant data meta-analysis (IPDMA). We pooled hazard ratios (HR) from Cox proportional-hazards models for 5-year mortality and estimates of linear mixed models for change in cognitive and functional decline. Models were stratified by BP-lowering treatment, history of CVD, Mini-Mental State Examination scores, grip strength (GS) and body mass index (BMI). Results: Of all 2480 participants (59.9% females, median 85 years), median baseline SBP was 149 mmHg, 64.3% used BP-lowering drugs and 47.3% had a history of CVD. Overall, higher SBP was associated with lower all-cause mortality (pooled HR 0.91 [95% confidence interval 0.88-0.95] per 10 mmHg). Associations remained irrespective of BP-lowering treatment, history of CVD and BMI, but were absent in octogenarians with above-median MMSE and GS. In pooled cohorts, SBP was not associated with cognitive and functional decline. Conclusion: While in the very old with low cognitive or physical fitness a higher SBP was associated with a lower all-cause mortality, this association was not evident in fit octogenarians. SBP was not consistently associated with cognitive and functional decline.
- Subjects :
- Aged, 80 and over
Male
cognition
Physiology
cardiovascular
blood pressure
body mass index
frailty
aged
Cardiovascular Diseases
Risk Factors
grip strength
Hypertension
Outcome Assessment, Health Care
Internal Medicine
Humans
Female
antihypertensive
Hypotension
Cardiology and Cardiovascular Medicine
activities of daily living
Antihypertensive Agents
older adults
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Hypertension, 40(9), 1786-1794. LIPPINCOTT WILLIAMS & WILKINS
- Accession number :
- edsair.doi.dedup.....ab4b545e3b6d30ef1e837800ac6263ee