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Characteristics of follicular fluid in ovaries with endometriomas
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology. 209:34-38
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The study of follicular fluid (FF) content nearby endometriomas may assist in elucidating pathophysiology, possible biomarkers related to this disease and the effect of endometriomas on ovarian physiology. As the question "how endometrioma may intrude the physiology of ovarian tissue?" is still open, we aimed to summarize the molecular evidence supporting the idea that endometriomas can negatively influence the content of the surrounding ovarian follicles. An alteration of the iron metabolism and an increased ROS (reactive oxygen species) generation characterize the intrafollicular environment adjacent to endometriomas. Other potentially negative effects include decreased testosterone and anti-Mullerian hormone FF levels although these have been only partially clarified. Alterations in lipid and proteomic patterns have been also observed in FF samples nearby endometriomas. The possibility that endometriomas per se may influence IVF clinical results as a consequence of the detrimental impact on the local intrafollicular environment is also discussed.
- Subjects :
- Proteomics
0301 basic medicine
endocrine system
medicine.medical_specialty
Iron
Endometriosis
Molecular evidence
Ovary
Follicular fluid
Decreased testosterone
Andrology
03 medical and health sciences
Ovarian physiology
0302 clinical medicine
Internal medicine
medicine
Humans
Endometrioma
Ovarian Diseases
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
medicine.disease
Pathophysiology
Follicular Fluid
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Reproductive Medicine
Female
Reactive Oxygen Species
business
Hormone
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 209
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....ab4b464d9134ad6db6378b9fdcaf60aa