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Retinal Micropseudocysts in Diabetic Retinopathy: Prospective Functional and Anatomic Evaluation
- Publication Year :
- 2011
-
Abstract
- Aim: To evaluate the prevalence, progression and functional predictive value of retinal micropseudocysts (MPCs) in diabetic patients. Methods: Prospective controlled observational study. From among all the type 2 diabetic patients evaluated during a period of 5 months between September 2009 and January 2010, we enrolled all patients with retinal MPCs at spectral-domain scanning laser ophthalmoscope/optical coherence tomography (SD-SLO/OCT) not previously treated for diabetic retinopathy. Forty diabetic patients without MPCs served as the control group. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), macular sensitivity and stability of fixation at SD-SLO/OCT microperimetry were measured monthly for 12 months. Results: 22/156 patients with type 2 diabetes (14.1%, 32 eyes) met the inclusion criteria. The 95% confidence interval for the prevalence estimate of MPCs was 12.3–16.6%. Mean BCVA, CRT and central retinal sensitivity at baseline were 77.53 ± 2.2 Early Treatment Diabetic Retinopathy Study letters, 242.31 ± 31.0 µm and 15.95 ± 0.61 dB, respectively. Fixation was stable in all cases. Compared to the control group, eyes with MPCs had similar BCVA but greater CRT (p = 0.01) and reduced macular sensitivity (p = 0.001) at baseline and at each follow-up visit. Over time, CRT remained stable in eyes with MPCs, whereas macular sensitivity progressively decreased. Conclusion: MPCs in diabetic retinopathy are associated, temporally or causally, with a progressive reduction of macular sensitivity despite a stable BCVA, CRT and fixation.
- Subjects :
- Male
medicine.medical_specialty
Visual acuity
genetic structures
Visual Acuity
Type 2 diabetes
Retina
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Retinal Diseases
Predictive Value of Tests
Diabetes mellitus
Ophthalmology
Prevalence
Medicine
Humans
Prospective Studies
Fixation (histology)
Aged
Diabetic Retinopathy
business.industry
Cysts
Retinal
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
eye diseases
Sensory Systems
Confidence interval
chemistry
Diabetes Mellitus, Type 2
Disease Progression
Optometry
Visual Field Tests
Female
sense organs
medicine.symptom
business
Microperimetry
Tomography, Optical Coherence
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ab494277b2b49aab857bba000b954997