Back to Search
Start Over
Tissue distribution of sialic acid-linked influenza virus receptors in beagle dogs
- Source :
- Journal of Veterinary Science
- Publication Year :
- 2012
- Publisher :
- The Korean Society of Veterinary Science, 2012.
-
Abstract
- Reports of influenza A virus infections in dogs has received considerable attention from veterinarians, virologists, and epidemiologists. Interaction between influenza viral hemagglutinin and cell oligosaccharides containing sialic acid residues results in infection. Sialic acids have an α-2,3-linkage to the penultimate galactose in the avian influenza virus receptor and an α-2,6-linkage in the human receptor. To date, there are no detailed data on the tissue distribution or histological features of either type of sialic acid-linked influenza virus receptors in beagle dogs, which are common laboratory animals and pets. We conducted the current study to visualize the in situ tissue distribution of both sialic acid-linked influenza virus receptors in various organs of beagle dogs using Maackia amurensis lectin II and Sambucus nigra agglutinin. Both α-2,3- and α-2,6-sialic acid-linked receptors were detected in the endothelial cells of the respiratory tract and other organs. Endothelial cells of most gastrointestinal organs were negative for α-2,3-sialic acid-linked receptors in the dogs. Our results suggested that these canine organs may be affected by influenza virus infection. The findings from our study will also help evaluate the occurrence and development of influenza virus infections in dogs.
- Subjects :
- Male
dogs
Receptors, Cell Surface
medicine.disease_cause
Beagle
Virus
Pathogenesis
chemistry.chemical_compound
Agglutinin
Orthomyxoviridae Infections
Sambucus nigra
Influenza A virus
medicine
Animals
Maackia
Dog Diseases
Receptor
Influenza A Virus, H5N1 Subtype
General Veterinary
biology
influenza virus receptors
Lectin
Virology
N-Acetylneuraminic Acid
Sialic acid
chemistry
sialic acid
Organ Specificity
biology.protein
lectin
Receptors, Virus
Original Article
Female
Plant Lectins
Subjects
Details
- ISSN :
- 1976555X and 1229845X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Science
- Accession number :
- edsair.doi.dedup.....ab465841ab149af8c901bb71069020ae