Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2]

The reaction of cis - and trans -[PtCl 2 (NCCH 2 Ph) 2 ] with a 5-fold excess of MeNH 2 and Me 2 NH in CH 2 Cl 2 at −10 °C affords in high yield the bis-amidine derivatives cis - and trans -[PtCl 2 { Z -N(H) C(NHMe)CH 2 Ph} 2 ] ( 1a , 2a ) and cis - and trans -[PtCl 2 { E -N(H) C(NMe 2 )CH 2 Ph} 2 ] ( 3a , 4a ), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans -[PtCl 2 { Z -N(H) C(NHMe)CH 2 Ph} 2 ] ( 2a ). Moreover, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines.