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BORA-dependent PLK1 regulation: A new weapon for cancer therapy?
- Source :
- Molecular & Cellular Oncology, Molecular & Cellular Oncology, Taylor et Francis, 2016, 3 (5), pp.e1199265. ⟨10.1080/23723556.2016.1199265⟩, Molecular & Cellular Oncology, Vol. 3, No 5 (2016) P. e1199265
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; The mitotic kinase polo like kinase 1 (PLK1) is overexpressed in many cancers and its inhibition slows down proliferation and increases apoptosis in cancer cell lines. Understanding how PLK1 is activated is therefore crucial for the development of novel PLK1 inhibitors with anticancer properties. We recently identified a conserved regulatory loop leading to PLK1 activation that involves cyclin-dependent kinase 1 (CDK1).
- Subjects :
- 0301 basic medicine
cell division
Cancer Research
CDK1
Polo-like kinase
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Cell cycle
PLK1
03 medical and health sciences
0302 clinical medicine
ddc:612
Author's View
Cyclin-dependent kinase 1
biology
Cyclin-dependent kinase 4
Kinase
Cyclin-dependent kinase 2
Cyclin-dependent kinase 3
3. Good health
Cell biology
030104 developmental biology
Apoptosis
030220 oncology & carcinogenesis
biology.protein
Cancer research
Molecular Medicine
DNA damage
Subjects
Details
- Language :
- English
- ISSN :
- 23723556
- Database :
- OpenAIRE
- Journal :
- Molecular & Cellular Oncology, Molecular & Cellular Oncology, Taylor et Francis, 2016, 3 (5), pp.e1199265. ⟨10.1080/23723556.2016.1199265⟩, Molecular & Cellular Oncology, Vol. 3, No 5 (2016) P. e1199265
- Accession number :
- edsair.doi.dedup.....ab3a4252b7afa70e986ee79e5b3ebff6