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Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome
- Source :
- Coppus, A M W, Schuur, M, Vergeer, J, Janssens, A C J W, Oostra, B A, Verbeek, M M & van Duijn, C M 2012, ' Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome ', Neurobiology of Aging, vol. 33, no. 9, pp. 1988-1994 . https://doi.org/10.1016/j.neurobiolaging.2011.08.007, Neurobiology of Aging, 33, 1988-94, Neurobiology of Aging, 33(9), 1988-1994. Elsevier Inc., Neurobiology of Aging, 33, 9, pp. 1988-94
- Publication Year :
- 2012
-
Abstract
- Extracellular deposition of amyloid beta peptide (A beta) has been implicated as a critical step in the pathogenesis of Alzheimer's disease (AD). In Down syndrome (DS), Alzheimer's disease is assumed to be caused by the triplication and overexpression of the gene for amyloid precursor protein (APP), located on chromosome 21. Plasma concentrations of A beta 1-40 and A beta 1-42 were determined in a population based study of 506 persons with DS, who were screened annually for dementia. We used Cox proportional hazards models to determine the risk of dementia. Demented persons with DS have a significantly higher plasma A beta 1-40 concentration than the nondemented (p = 0.05). Those with the highest concentrations of A beta 1-40 and A beta 1-42 have a higher risk to develop dementia. The risk to develop dementia during follow-up (mean 4.7 years) increased to 2.56 (95% confidence interval, 1.39-4.71) for A beta 1-42 and 2.16 (95% confidence interval, 1.14-4.10) for A beta 1-40. High plasma concentration of plasma A beta 1-40 and A beta 1-42 are determinants of the risk of dementia in persons with DS. (C) 2012 Elsevier Inc. All rights reserved.
- Subjects :
- Male
Aging
Pathology
Down syndrome
Pathogenesis
Disability Evaluation
Amyloid precursor protein
Netherlands
Aged, 80 and over
biology
General Neuroscience
Effective primary care and public health [NCEBP 7]
Middle Aged
Alzheimer's disease
Female
medicine.medical_specialty
Amyloid beta
DCN MP - Plasticity and memory
Neuroscience(all)
Clinical Neurology
Community Health Planning
Alzheimer Disease
International Classification of Diseases
Internal medicine
mental disorders
medicine
Humans
Dementia
DCN NN - Brain networks and neuronal communication
Aged
Proportional Hazards Models
Retrospective Studies
Amyloid beta-Peptides
business.industry
Proportional hazards model
medicine.disease
Peptide Fragments
Confidence interval
Ageing
Endocrinology
nervous system
biology.protein
Abeta
Neurology (clinical)
Geriatrics and Gerontology
business
Chromosome 21
Follow-Up Studies
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....ab38c37f629277158147b07b1b28feb3