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Vascular endothelial growth factor -634G/C and vascular endothelial growth factor -2578C/A polymorphisms and lung cancer risk: a case-control study and meta-analysis
- Source :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(3)
- Publication Year :
- 2013
-
Abstract
- Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis. In present study, we conducted a case–control study and meta-analysis to evaluate the genetic effects of VEGF -634G/C and VEGF -2578C/A polymorphisms and risk of lung cancer. A total of 175 subjects were recruited for case–control study and seven studies were included in the meta-analysis. Our case–control study showed that VEGF -634G/C polymorphism had no association with lung cancer risk (CC vs. GG: OR = 0.88, 95 % CI = 0.37–2.11), whereas there was an association between VEGF -2578CC genotype and decrease in lung cancer risk (CC vs. CA/AA: OR = 0.52, 95 % CI = 0.28–0.96). A meta-analysis was further performed and statistically similar results were obtained (CC vs. GG: OR = 0.91, 95 % CI = 0.60–1.39 for VEGF −634; CC vs. AA: OR = 0.53, 95 % CI = 0.32–0.89 for VEGF −2578). Our study showed that the variant genotypes of the VEGF -2578C/A polymorphism, but not the VEGF -634G/C polymorphism, was associated with lung cancer risk. More studies are needed to detect VEGF -634G/C and VEGF −2578 polymorphisms and their association with lung cancer in different ethnic populations incorporated with environmental exposures.
- Subjects :
- Oncology
Adult
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Lung Neoplasms
Angiogenesis
VEGF receptors
Vascular Endothelial Growth Factor C
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Metastasis
chemistry.chemical_compound
Risk Factors
Internal medicine
Genotype
medicine
Humans
Genetic Predisposition to Disease
Lung cancer
Aged
biology
business.industry
Carcinoma
Case-control study
General Medicine
Middle Aged
medicine.disease
Vascular endothelial growth factor
chemistry
Meta-analysis
Case-Control Studies
Immunology
biology.protein
Female
business
Subjects
Details
- ISSN :
- 14230380
- Volume :
- 35
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....ab3698ac03d41fb839322447e8297317