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Plasma 7B2 (a novel pituitary protein) immunoreactivity concentrations in patients with various endocrine disorders
- Source :
- Endocrinologia japonica. 35(4)
- Publication Year :
- 1988
-
Abstract
- We have measured plasma 7B2 (a novel pituitary protein)-immunoreactivity (IR) concentrations in patients with various endocrine disorders. Mean (+/- SEM) basal plasma 7B2-IR concentrations (ng/L) in patients with acromegaly (81 +/- 14.6), Cushing's disease (57.2 +/- 8.5), prolactinoma (71.4 +/- 9.5), panhypopituitarism (50.6 +/- 7.6), isolated ACTH deficiency (47.9 +/- 11.6), hyperthyroidism (57.9 +/- 6.7) and hypothyroidism (60.8 +/- 9.4) were on the same levels as those in age-matched normal subjects. However, basal plasma 7B2-IR concentrations were increased to more than 100 ng/L in 5 out of 25 patients with acromegaly (20%). Mean basal plasma 7B2-IR concentrations in patients with medullary carcinoma of the thyroid and pheochromocytoma were 293 +/- 38.1 ng/L (range: 225.7-357.4 ng/L, n = 3) and 221 +/- 82.8 ng/L (range: 48.5-527.8 ng/L, n = 5), respectively, and significantly higher than those in age-matched normal subjects (P less than 0.001). These results suggest that plasma 7B2-IR may have some diagnostic value for acromegaly and may be useful as a marker for medullary carcinoma of the thyroid and pheochromocytoma.
- Subjects :
- Adult
Male
Pituitary gland
medicine.medical_specialty
Adolescent
Nerve Tissue Proteins
Endocrine System Diseases
Hyperthyroidism
Hypopituitarism
Pheochromocytoma
Basal (phylogenetics)
Neuroendocrine Secretory Protein 7B2
Endocrinology
Adrenocorticotropic Hormone
Hypothyroidism
Internal medicine
Acromegaly
medicine
Endocrine system
Humans
Prolactinoma
Cushing Syndrome
Aged
business.industry
Thyroid
General Engineering
Middle Aged
medicine.disease
Pituitary Hormones
medicine.anatomical_structure
Medullary carcinoma
Female
business
Subjects
Details
- ISSN :
- 00137219
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Endocrinologia japonica
- Accession number :
- edsair.doi.dedup.....ab2d662d8bdcaa7df537604200d965c5