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Comparison of SDOCT Scan Types for Grading Disorganization of Retinal Inner Layers and Other Morphologic Features of Diabetic Macular Edema
- Source :
- Translational Vision Science & Technology
- Publication Year :
- 2020
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2020.
-
Abstract
- Purpose To assess grading reproducibility of disorganization of the retinal inner layers (DRIL) and other morphologic features of diabetic macular edema (DME) across spectral domain optical coherence tomography (SDOCT) instruments and scan types. Methods A cross-sectional study enrolled participants with current or recent center-involved DME. In group A (27 eyes), we obtained two Cirrus scans (512 × 128 macular cube [Cube] and high-definition five-line raster [HD 5-Line]) and two Spectralis scans (high-resolution [HR] and high-speed [HS]). In group B, 26 eyes underwent HR scans and Optovue AngioVue (OP) 3 × 3-mm scans. All scans were graded for type and extent of DRIL, intraretinal cysts, cone outer segment tip visibility, and subretinal fluid (SRF). Results In the total cohort, mean central subfield thickness was 342.9 ± 83.4 µm. Intraclass correlations were high for DRIL extent across the four different imaging settings (HR vs. HS, r = 0.93; HR vs. Cube, r = 0.84, HR vs. HD 5-Line, r = 0.76, HR vs. OP, r = 0.87) and ranged from good to excellent for intraretinal cyst and SRF area. There were significantly smaller mean normalized differences between HR/HS scans versus HR and all other scan modalities (HR/HS vs. HR/Cube, P = 0.02; HR/HD 5-Line, P = 0.0005; HR/OP, P < 0.0001). Conclusions Our data suggest that the reproducibility for SDOCT parameters of DRIL and intraretinal cysts was high across all five SDOCT scan types; thus, evaluation of DRIL is feasible using multiple SDOCT models in eyes with DME. Translational Relevance DME morphological changes can be evaluated on multiple SDOCT devices with good reproducibility, allowing clinicians and researchers flexibility in DME assessment for clinical care and research.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
genetic structures
Diabetic macular edema
Visual Acuity
Biomedical Engineering
Scan types
DRIL
Spectral domain
Article
Macular Edema
03 medical and health sciences
chemistry.chemical_compound
disorganization of retinal inner layers
0302 clinical medicine
Optical coherence tomography
Ophthalmology
Diabetes Mellitus
medicine
Humans
Fluorescein Angiography
Grading (tumors)
Retrospective Studies
Reproducibility
Diabetic Retinopathy
medicine.diagnostic_test
business.industry
Reproducibility of Results
Retinal
Diabetic retinopathy
medicine.disease
Cross-Sectional Studies
030104 developmental biology
chemistry
030221 ophthalmology & optometry
SDOCT
diabetic macular edema
business
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 21642591
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Translational Vision Science & Technology
- Accession number :
- edsair.doi.dedup.....ab24eda877d75123d4663a8cd71185e0