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Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury
- Source :
- BioMed Research International, BioMed Research International, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Acute lung injury (ALI) is a life-threatening clinical syndrome with high morbidity and mortality. The main pathological features of ALI are increased alveolar-capillary membrane permeability, edema, uncontrolled migration of neutrophils to the lungs, and diffuse alveolar damage, resulting in acute hypoxemic respiratory failure. Glucocorticoids, aspirin, and other anti-inflammatory drugs are commonly used to treat ALI. Respiratory supports, such as a ventilator, are used to alleviate hypoxemia. Many treatment methods are available, but they cannot significantly ameliorate the quality of life of patients with ALI and reduce mortality rates. Herbal active ingredients, such as flavonoids, terpenoids, saponins, alkaloids, and quinonoids, exhibit advantages for ALI prevention and treatment, but the underlying mechanism needs further study. This paper summarizes the role of herbal active ingredients in anti-ALI therapy and progresses in the understanding of their mechanisms. The work also provides some references and insights for the discovery and development of novel drugs for ALI prevention and treatment.
- Subjects :
- medicine.medical_specialty
Membrane permeability
Acute Lung Injury
Phytochemicals
Review Article
Lung injury
General Biochemistry, Genetics and Molecular Biology
Hypoxemia
Edema
Humans
Medicine
Respiratory system
Intensive care medicine
Diffuse alveolar damage
Aspirin
General Immunology and Microbiology
business.industry
Mortality rate
General Medicine
respiratory system
respiratory tract diseases
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....ab070328a739512cdbce07ed7794874f
- Full Text :
- https://doi.org/10.1155/2021/5543185