Back to Search Start Over

Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury

Authors :
Yue-Guo Wu
Chun-Xiao Gao
Chen-Huan Yu
Huan-Huan Zhang
Wen-Ying Yu
Source :
BioMed Research International, BioMed Research International, Vol 2021 (2021)
Publication Year :
2021
Publisher :
Hindawi Limited, 2021.

Abstract

Acute lung injury (ALI) is a life-threatening clinical syndrome with high morbidity and mortality. The main pathological features of ALI are increased alveolar-capillary membrane permeability, edema, uncontrolled migration of neutrophils to the lungs, and diffuse alveolar damage, resulting in acute hypoxemic respiratory failure. Glucocorticoids, aspirin, and other anti-inflammatory drugs are commonly used to treat ALI. Respiratory supports, such as a ventilator, are used to alleviate hypoxemia. Many treatment methods are available, but they cannot significantly ameliorate the quality of life of patients with ALI and reduce mortality rates. Herbal active ingredients, such as flavonoids, terpenoids, saponins, alkaloids, and quinonoids, exhibit advantages for ALI prevention and treatment, but the underlying mechanism needs further study. This paper summarizes the role of herbal active ingredients in anti-ALI therapy and progresses in the understanding of their mechanisms. The work also provides some references and insights for the discovery and development of novel drugs for ALI prevention and treatment.

Details

ISSN :
23146141 and 23146133
Volume :
2021
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....ab070328a739512cdbce07ed7794874f
Full Text :
https://doi.org/10.1155/2021/5543185