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Blood Protein Concentrations in the First Two Postnatal Weeks That Predict Bronchopulmonary Dysplasia Among Infants Born Before the 28th Week of Gestation
- Source :
- Pediatric Research. 69:347-353
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Lung inflammation contributes to the pathogenesis of bronchopulmonary dysplasia (BPD) and may be accompanied by a systematic inflammatory response. The objective of this study was to investigate the role of systemic inflammation in the development of BPD in a cohort of extremely low gestational age newborns (ELGANs) by examining the relationships between inflammation-associated proteins in neonatal blood samples and pulmonary outcomes. Proteins were measured in blood specimens collected on postnatal days 1–3, 5–8 and 12–15 from 932 ELGANs. Increased risk of BPD was associated with elevated blood concentrations of a variety of pro-inflammatory cytokines, adhesion molecules and proteases. Reduced risk was prominently associated with increased concentrations of one chemokine, RANTES. Elevations of inflammatory proteins associated with BPD risk occurred during the first days following birth, and inflammation intensified thereafter. Therefore, exposures that promote inflammation after the first postnatal days may be more critical in the pathogenesis of BPD. Fetal growth restriction, a known BPD risk factor, was not accompanied by proteins elevations and therefore does not appear to be mediated by systemic inflammation. By contrast, mechanical ventilation altered protein levels and may be associated with systemic inflammation.
- Subjects :
- Chemokine
Physiology
Gestational Age
Inflammation
Systemic inflammation
Article
Proinflammatory cytokine
Cohort Studies
Pathogenesis
Pregnancy
Risk Factors
mental disorders
Odds Ratio
Humans
Medicine
Risk factor
Bronchopulmonary Dysplasia
biology
business.industry
Infant, Newborn
Blood Proteins
Pneumonia
medicine.disease
Blood proteins
Bronchopulmonary dysplasia
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
Cytokines
Female
Chemokines
medicine.symptom
business
Infant, Premature
Subjects
Details
- ISSN :
- 15300447 and 00313998
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Pediatric Research
- Accession number :
- edsair.doi.dedup.....ab04b72aefa8e8828436d181b5f26a87