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Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases
- Source :
- Future medicinal chemistry. 5(17)
- Publication Year :
- 2013
-
Abstract
- There are several lines of laboratory-based evidence emerging to suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy, Duchenne muscular dystrophy and Charcot–Marie–Tooth disease. Here, we critically examine the scientific evidence related to the known molecular effects that these polyphenols have on different models of inherited neuromuscular disease, with particular attention to problems with the validity of in vitro evidence. We also present proteomic evidence that polyphenols have in vitro effects on cells related to metal ion chelation in cell-culture media. Although their precise mechanisms of action remain somewhat elusive, polyphenols could be an attractive approach to therapy for inherited neuromuscular disease, especially since they may be safer to use on young children, compared with some of the other drug candidates.
- Subjects :
- Drug
Neuromuscular disease
media_common.quotation_subject
Duchenne muscular dystrophy
Disease
Resveratrol
Biology
Pharmacology
chemistry.chemical_compound
Drug Discovery
medicine
Animals
Humans
media_common
food and beverages
Polyphenols
Spinal muscular atrophy
Neuromuscular Diseases
Plants
medicine.disease
Biochemistry
chemistry
Polyphenol
Curcumin
Molecular Medicine
Plant Preparations
Subjects
Details
- ISSN :
- 17568927
- Volume :
- 5
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- Future medicinal chemistry
- Accession number :
- edsair.doi.dedup.....ab00b918ad8c9ed06673e4ed2e521337