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The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines
- Source :
- Oncotarget
- Publication Year :
- 2016
- Publisher :
- Impact Journals, LLC, 2016.
-
Abstract
- GPBAR1 (also known as TGR5) is a bile acid activated receptor expressed in several adenocarcinomas and its activation by secondary bile acids increases intestinal cell proliferation. Here, we have examined the expression of GPBAR1 in human gastric adenocarcinomas and investigated whether its activation promotes the acquisition of a pro-metastatic phenotype. By immunohistochemistry and RT-PCR analysis we found that expression of GPBAR1 associates with advanced gastric cancers (Stage III-IV). GPBAR1 expression in tumors correlates with the expression of N-cadherin, a markers of epithelial-mesenchymal transition (EMT) (r=0.52; P
- Subjects :
- Male
0301 basic medicine
Pathology
Bile acids
Epithelial-mesenchymal transition
Gastric cancer
TGR5
Mice, SCID
Receptors, G-Protein-Coupled
Mice
0302 clinical medicine
Cell Movement
Mice, Inbred NOD
Receptor
Aged, 80 and over
biology
Bile acid
Hep G2 Cells
Middle Aged
Cadherins
G protein-coupled bile acid receptor
Gene Expression Regulation, Neoplastic
Hyaluronan Receptors
Oncology
030220 oncology & carcinogenesis
Female
Peritoneum
Research Paper
medicine.medical_specialty
medicine.drug_class
Chenodeoxycholic Acid
03 medical and health sciences
Antigens, CD
Stomach Neoplasms
Cell Line, Tumor
Cell Adhesion
medicine
Animals
Humans
Epithelial–mesenchymal transition
Oleanolic Acid
Cell adhesion
Aged
Cell Proliferation
Wound Healing
Cadherin
Cell growth
CD44
digestive system diseases
030104 developmental biology
biology.protein
Cancer research
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....ab004f146584240b94138cc25367deef