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Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries
- Publication Year :
- 2009
- Publisher :
- Elsevier, 2009.
-
Abstract
- The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries. The glass transition of this amorphous protein was investigated by Differential Scanning Calorimetry (DSC). To explore the molecular dynamics of the elastin network in the nanometer range, we used Thermally Stimulated Currents (TSC), a dielectric technique running at low frequency and measuring the dipolar reorientations in proteins subjected to a static electrical field. Combining TSC and DSC experiments with determination of the activation parameters of relaxation times reveals the molecular mobility of the proteins. The major differences in the relaxation behavior of elastin between arteries cultured with physiological and pathological concentrations of homocysteine are discussed.
- Subjects :
- Homocysteine
biology
Matériaux
Dielectric
Condensed Matter Physics
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
Molecular dynamics
Differential scanning calorimetry
Biochemistry
chemistry
Circulatory system
Materials Chemistry
Ceramics and Composites
biology.protein
Biophysics
Thermally stimulated and depolarization current
Relaxation (physics)
Glass transition
Elastin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....aafcf012a46491241f235f8826cb573c