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Enhancement of cortisol measurement sensitivity by laser illumination for AlGaN/GaN transistor biosensor
- Source :
- Biosensorsbioelectronics. 159
- Publication Year :
- 2020
-
Abstract
- In this study, high electron mobility transistor (HEMT) device was used as an immuno biosensor to measure concentration of a stress hormone, cortisol, by using selective binding on cortisol monoclonal antibody (c-Mab). Also, the HEMT sensor was enhanced in its sensitivity through light illumination to generate photocurrent. The optical pumping could assist the biosensor to discriminate more detailed change, which could result in an increment of limit of detection (LOD) to 1.0 pM cortisol level. It was the lowest level of detection with semiconductor device-based cortisol biosensors and the enhancement of surface potential sensitivity was induced by laser light (532 nm). Output current amplificated by photocurrent was higher than dark original current at about 3.39% when gate voltage is applied with −3 V. Since the device could be applied to not only standard cortisol solution but also real human salivary sample, it is expected to apply for in vitro direct diagnosis of point-of-care test (POCT).
- Subjects :
- Materials science
Hydrocortisone
Transistors, Electronic
Biomedical Engineering
Biophysics
Gallium
02 engineering and technology
High-electron-mobility transistor
Biosensing Techniques
01 natural sciences
law.invention
Optical pumping
law
Electrochemistry
Humans
Aluminum Compounds
Detection limit
Photocurrent
business.industry
Lasers
010401 analytical chemistry
Transistor
General Medicine
Semiconductor device
Microfluidic Analytical Techniques
021001 nanoscience & nanotechnology
0104 chemical sciences
Optoelectronics
0210 nano-technology
business
Biosensor
Sensitivity (electronics)
Biotechnology
Subjects
Details
- ISSN :
- 18734235
- Volume :
- 159
- Database :
- OpenAIRE
- Journal :
- Biosensorsbioelectronics
- Accession number :
- edsair.doi.dedup.....aafa492e02bad05a77ae4abec13e1ff9