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An illustrated consensus on the classification of pancreatic Intraepithelial neoplasia and intraductal papillary mucinous neoplasms
- Source :
- American journal of surgical pathology, 28(8), 977-987. Lippincott Williams and Wilkins
- Publication Year :
- 2004
-
Abstract
- Invasive pancreatic ductal adenocarcinoma is an almost uniformly fatal disease. Several distinct noninvasive precursor lesions can give rise to invasive adenocarcinoma of the pancreas, and the prevention, detection, and treatment of these noninvasive lesions offers the potential to cure early pancreatic cancers. Noninvasive precursors of invasive ductal adenocarcinoma of the pancreas include pancreatic intraepithelial neoplasias (PanINs), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms. Diagnostic criteria, including a distinct ovarian-type stroma, and a consistent nomenclature are well established for mucinous cystic neoplasms. By contrast, consistent nomenclatures and diagnostic criteria have been more difficult to establish for PanINs and IPMNs. Because both PanINs and IPMNs consist of intraductal neoplastic proliferations of columnar, mucin-containing cells with a variable degree of papilla formation, the distinction between these two classes of precursor lesions remains problematic. Thus, considerable ambiguities still exist in the classification of noninvasive neoplasms in the pancreatic ducts. A meeting of international experts on precursor lesions of pancreatic cancer was held at The Johns Hopkins Hospital from August 18 to 19, 2003. The purpose of this meeting was to define an international acceptable set of diagnostic criteria for PanINs and IPMNs and to address a number of ambiguities that exist in the previously reported classification systems for these neoplasms. We present a consensus classification of the precursor lesions in the pancreatic ducts, PanINs and IPMNs.
- Subjects :
- Pathology
medicine.medical_specialty
Consensus
endocrine system diseases
Pancreatic Intraepithelial Neoplasia
Cystadenocarcinoma, Mucinous
Pathology and Forensic Medicine
Pancreatic cancer
medicine
Humans
Cystadenocarcinoma
Intraepithelial neoplasia
Intraductal papillary mucinous neoplasm
business.industry
Carcinoma in situ
medicine.disease
Pancreatic Neoplasms
medicine.anatomical_structure
Practice Guidelines as Topic
Cystadenocarcinoma, Papillary
Adenocarcinoma
Surgery
Anatomy
Pancreas
business
Carcinoma in Situ
Carcinoma, Pancreatic Ductal
Subjects
Details
- Language :
- English
- ISSN :
- 01475185
- Volume :
- 28
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- American journal of surgical pathology
- Accession number :
- edsair.doi.dedup.....aaf53e43c77dc513b612008e77f64969