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Signal amplification strategies for paper-based analytical devices
- Source :
- Biosensorsbioelectronics. 136
- Publication Year :
- 2019
-
Abstract
- Paper-based analytical devices (PADs) are very popular for point-of-care diagnostics, which provide a fast, cost-effective and possible multiplexed detection of a spectrum of molecules. They have been matching forward proudly to contribute to the modern analytical science and life science. Accompanying with their advantages and huge potentials, low detection sensitivity is continuing to challenge the application of PADs from bench to bedside. In order to improve the sensitivity and enhance the signal readout, variable signal amplification strategies have been investigated and applied for PADs. In this review, we have firstly classified formats of PADs according to the engineering design. Advances for improving sensitivity of PADs in recent five years are then summarised according to three popular types of signal amplification strategies (nanomaterial based, nucleic acid based, and engineering of PADs based). Pros and cons of each signal amplification approach have been discussed accordingly. Finally, the future perspectives of PADs are proposed.
- Subjects :
- Paper
Computer science
Point-of-Care Systems
Biomedical Engineering
Biophysics
02 engineering and technology
Biosensing Techniques
01 natural sciences
Multiplexing
Signal
Electrochemistry
Electronic engineering
Humans
010401 analytical chemistry
General Medicine
Analytical science
Paper based
Microfluidic Analytical Techniques
021001 nanoscience & nanotechnology
Bench to bedside
0104 chemical sciences
Nanoparticles
Reagent Kits, Diagnostic
0210 nano-technology
Engineering design process
Sensitivity (electronics)
Signal amplification
Biotechnology
Subjects
Details
- ISSN :
- 18734235
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- Biosensorsbioelectronics
- Accession number :
- edsair.doi.dedup.....aaf0a384d49d7deb2b97454f3dfe1037