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Unexpected higher blood loss associated with higher dose ϵ-aminocaproic acid in pediatric scoliosis surgery
- Source :
- Journal of Pediatric Orthopaedics B. 28:40-44
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- The purpose of this study was to determine if a higher dosing of ε-aminocaproic acid (EACA) is associated with less perioperative blood loss than a lower dose. A total of 74 patients having scoliosis surgery were analyzed. Of the 74 patients, 36 patients received EACA (10 mg/kg/h) and 38 patients received EACA (33 mg/kg/h). After controlling for key variables, an infusion of 33 mg/kg/h of EACA was associated with an increase in intraoperative blood loss of 8.1 ml/kg compared with an infusion of 10 mg/kg/h of EACA. A 33 mg/kg/h intraoperative infusion is associated with higher intraoperative blood loss than an infusion at 10 mg/kg/h.
- Subjects :
- Male
Adolescent
Blood Loss, Surgical
Scoliosis
03 medical and health sciences
0302 clinical medicine
Blood loss
Antifibrinolytic agent
medicine
Humans
Orthopedics and Sports Medicine
Dosing
Infusions, Intravenous
Retrospective Studies
030222 orthopedics
Dose-Response Relationship, Drug
business.industry
Retrospective cohort study
medicine.disease
Antifibrinolytic Agents
Perioperative blood loss
Scoliosis surgery
Anesthesia
Aminocaproic Acid
Pediatrics, Perinatology and Child Health
Female
Aminocaproic acid
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 1060152X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Orthopaedics B
- Accession number :
- edsair.doi.dedup.....aad8dd3a4d515d8067bfb2ddafcec417