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The Influence of Wiring Economy on Nervous System Evolution
- Source :
- Current Biology. 26:R1101-R1108
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The activity and maintenance of neurons requires substantial metabolic energy, resulting in selective pressure to decrease resource consumption by the nervous system. The wiring economy principle proposes that animals have evolved mechanisms that wire circuits efficiently by minimizing neurite length. Computational modeling of neuronal morphology, microcircuit organization, and neural networks reveals that wiring economy is a significant determinant of nervous system layout. The strategies for reducing wiring costs are shared across phyla and point to the possibility of generalizable rules that specify the development of efficient nervous systems. As the developmental mechanisms underpinning wiring economy are only now being elucidated, whether the molecular basis of this phenomenon is the result of conserved genetic programs or convergent evolution remains to be determined.
- Subjects :
- 0301 basic medicine
Nervous system
Metabolic energy
Artificial neural network
Models, Neurological
Computational Biology
Biological evolution
Biology
Biological Evolution
Invertebrates
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Economy
Vertebrates
medicine
Animals
Nervous System Physiological Phenomena
Resource consumption
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09609822
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Current Biology
- Accession number :
- edsair.doi.dedup.....aad752da1d5cfe192e9ef90afabe8183