Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Authors :: Alasdair Smith
Richard J. Wall
Stephen Patterson
Tim Rowan
Eva Rico Vidal
Laste Stojanovski
Margaret Huggett
Shahienaz E. Hampton
Michael G. Thomas
Victoriano Corpas Lopez
Kirsten Gillingwater
Jeff Duke
Grant Napier
Rose Peter
Hervé S. Vitouley
Justin R. Harrison
Rachel Milne
Laura Jeacock
Nicola Baker
Susan H. Davis
Frederick Simeons
Jennifer Riley
David Horn
Reto Brun
Fabio Zuccotto
Michael J Witty
Susan Wyllie
Kevin D. Read
Ian H. Gilbert
Source :: Journal of medicinal chemistry. 65(7)
Publication Year :: 2022
Abstract: African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites

Subjects :: Trypanosomiasis, African
Trypanosoma congolense
Drug Discovery
Drug Repositioning
Molecular Medicine
Animals
Cattle
Trypanosoma vivax
Cyclin-Dependent Kinases

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