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The Notch signaling pathway in head and neck squamous cell carcinoma: A meta-analysis
- Source :
- Advances in Clinical and Experimental Medicine. 26:881-887
- Publication Year :
- 2017
- Publisher :
- Wroclaw Medical University, 2017.
-
Abstract
- Background The Notch signaling pathway has been associated with the regulation of self-renewal capacity, cell cycle exit, and survival. However, the relationship between the Notch signaling pathway and HNSCC remains controversial. Objectives A meta-analysis was conducted to evaluate the role of Notch signaling pathway in HNSCC. Material and methods Relevant studies published until March 31, 2015 were identified by searching the PubMed, EMBASE and Ovid database. Results A total of 9 articles were eligible for this meta-analysis. The meta-analysis results showed that the expression of Notch1, Notch3 and NICD was significantly higher in HNSCC as compared with control tissue. There was no significant difference in Jagged1 and HES1 expression between HNSCC and control tissue. Stratified analysis results showed that the expression of Notch1 was significantly higher in poor differentiation, III and IV stage and positive lymph node metastasis patients. Additionally, over-expression of Notch1, NICD, HES1 and DLL4 significantly predicted poor OS in HNSCC patients. Conclusion The Notch signaling pathway plays an important role in tumor development of HNSCC. Inhibition of the Notch signaling pathway is a potential therapeutic method of HNSCC.
- Subjects :
- 0301 basic medicine
Time Factors
Notch signaling pathway
Medicine (miscellaneous)
Disease-Free Survival
General Biochemistry, Genetics and Molecular Biology
Metastasis
03 medical and health sciences
0302 clinical medicine
Risk Factors
Odds Ratio
Internal Medicine
medicine
Humans
Pharmacology (medical)
Receptor, Notch1
HES1
Stage (cooking)
Genetics (clinical)
Adaptor Proteins, Signal Transducing
Neoplasm Staging
Receptors, Notch
Squamous Cell Carcinoma of Head and Neck
business.industry
Calcium-Binding Proteins
Significant difference
Cell Differentiation
Cell cycle
medicine.disease
Survival Analysis
Head and neck squamous-cell carcinoma
Gene Expression Regulation, Neoplastic
stomatognathic diseases
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Meta-analysis
Reviews and References (medical)
Carcinoma, Squamous Cell
Cancer research
Intercellular Signaling Peptides and Proteins
Transcription Factor HES-1
business
Jagged-1 Protein
Signal Transduction
Subjects
Details
- ISSN :
- 18995276
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Advances in Clinical and Experimental Medicine
- Accession number :
- edsair.doi.dedup.....aab1e44171a87537b76ed77a0b4efcfa