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Cigarette smoking and prostate cancer-specific mortality following diagnosis in middle-aged men
- Source :
- Cancer Causes & Control. 19:25-31
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Objective The aim of this study was to examine associations of smoking at the time of diagnosis with the risk of prostate cancer death in a population-based cohort of men with prostate cancer. Methods Data were from 752 prostate cancer patients aged 40-64 years, who were enrolled in a case-control study and under long-term follow-up for mortality. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between smoking and prostate cancer-specific and other cause mortality. Results Compared to never smoking, smoking at the time of diagnosis was associated with a significant increase in risk of prostate cancer-specific mortality. After controlling for demographic characteristics, Gleason grade, stage at diagnosis, and primary treatment, the HR was 2.66 (95% CI: 1.10-6.43). Conclusions Smoking at the time of diagnosis, independent of key clinical prognostic factors, is associated with an increased risk of prostate cancer death.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Population
Prostate cancer
Prostate
Internal medicine
Epidemiology
medicine
Humans
education
education.field_of_study
Proportional hazards model
business.industry
Smoking
Hazard ratio
Prostatic Neoplasms
Middle Aged
medicine.disease
Survival Analysis
Confidence interval
Survival Rate
medicine.anatomical_structure
Cohort
business
Subjects
Details
- ISSN :
- 15737225 and 09575243
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Cancer Causes & Control
- Accession number :
- edsair.doi.dedup.....aaa23f4328b5cf3d04e52e5f31441071