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Albumin nanocapsules containing fenretinide: pre-clinical evaluation of cytotoxic activity in experimental models of human non-small cell lung cancer
- Publication Year :
- 2015
-
Abstract
- The present study deals with the preparation of albumin nanocapsules containing fenretinide and their evaluation in experimental models of human non-small cell lung cancer. These nanocapsules showed enhanced antitumor activity with respect to free fenretinide due to the solubilization effect of albumin on the hydrophobic drug, known to improve bioavailability. The high expression of caveolin-1 on the A549 cell surface further enhanced the antitumor activity of the nanoencapsulated fenretinide. Caveolin-1 favored albumin uptake and improved the efficacy of the fenretinide-loaded albumin nanocapsules, especially in 3-D cultures where the densely packed 3-D structures impaired drug diffusibility and severely reduced the activity of the free drug. The efficacy of the fenretinide albumin nanocapsules was further confirmed in tumor xenograft models of A549 by the significant delay in tumor progression observed with respect to control after intravenous administration of the novel formulation. From the Clinical Editor This study describes the preparation of fenretinide containing albumin nanocapsules and their evaluation in experimental models of non-small cell lung cancer, showing enhanced antitumor activity compared to free fenretinide.
- Subjects :
- Drug
IN VITRO EXPERIMENTS
Materials science
media_common.quotation_subject
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Biological Availability
Bioengineering
Antineoplastic Agents
Pharmacology
Nanocapsules
chemistry.chemical_compound
Mice
Albumins
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
medicine
Animals
Humans
General Materials Science
Lung cancer
media_common
A549 cell
Albumin
medicine.disease
Xenograft Model Antitumor Assays
Bioavailability
Fenretinide
chemistry
Tumor progression
Molecular Medicine
FENRETINIDE
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....aa8e6a65144a9a6eea19aa91604fe7fb