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Antimicrobial resistance and virulence-associated genes of Salmonella enterica subsp. enterica serotypes Muenster, Florian, Omuna, and Noya strains isolated from clinically diarrheic humans in Egypt
- Source :
- Microbial drug resistance (Larchmont, N.Y.). 19(5)
- Publication Year :
- 2013
-
Abstract
- Four serotypes recovered from clinically diarrheic human faecal samples (Salmonella Muenster, Salmonella Florian, Salmonella Omuna and Salmonella Noya) were investigated for the presence of 11 virulence genes (invA, avrA, ssaQ, mgtC, siiD, sopB, gipA, sodC1, sopE1, spvC, and bcfC) and their association with antibiotic resistance. The 4 Salmonella serotypes lacked virulence genes gipA and spvC. Resistance to 7 of the 14 antimicrobials was detected. The frequency of resistance, to lincomycin and streptomycin (100% of the Salmonella Muenster [2/5], Salmonella Florian [1/5], Salmonella Omuna [1/5], and Salmonella Noya [1/5] isolates), chloramphenicol (100% of the Salmonella Muenster [2/5] and Salmonella Florian [1/5] isolates) and trimethoprim-sulfamethoxazole (100% of the Salmonella Florian [1/5] and Salmonella Omuna [1/5] isolates) was an outstanding feature. With the rest of the antibiotics, the four Salmonella serotypes exhibited a great diversity in their resistance patterns. Overall, the four Salmonella serotypes were resistant to more than one antimicrobial. The antimicrobials to which the Salmonella Muenster, Salmonella Florian, and Salmonella Omuna isolates were resistant, contributed to five different antimicrobial resistance profiles. The virulence associated genes invA, ssaQ, siiD, sopB, and bcfC genes were 100% associated with certain antimicrobial resistance phenotypes (streptomycin and lincosamide) not recorded previously, and secondly, the presence of invA, avrA, ssaQ, mgtC, siiD, sopB, and bcfC was associated with resistance to chloramphenicol. The results of this study will help in understanding the spread of virulence genotypes and antibiotic resistance in Salmonella in the region of study.
- Subjects :
- Microbiology (medical)
Serotype
Adult
Diarrhea
Male
Salmonella
Adolescent
Virulence Factors
Immunology
Virulence
medicine.disease_cause
Microbiology
Feces
Antibiotic resistance
Drug Resistance, Multiple, Bacterial
Trimethoprim, Sulfamethoxazole Drug Combination
medicine
Humans
Child
Aged
Pharmacology
Aged, 80 and over
biology
Infant
Salmonella enterica
Gene Expression Regulation, Bacterial
Middle Aged
biology.organism_classification
Virology
Lincomycin
Anti-Bacterial Agents
Chloramphenicol
Streptomycin
Child, Preschool
Salmonella Infections
Salmonella enterica subsp. enterica
Egypt
Female
medicine.drug
Subjects
Details
- ISSN :
- 19318448
- Volume :
- 19
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Microbial drug resistance (Larchmont, N.Y.)
- Accession number :
- edsair.doi.dedup.....aa84c633896b601ab8c1051e2729848f