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Cerebral blood flow changes during aging process and in cognitive disorders: A review
- Source :
- The Neuroradiology Journal
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- We aimed to summarize the available evidence on cerebral blood flow (CBF) changes in normal aging and common cognitive disorders. We searched PubMed for studies on CBF changes in normal aging and cognitive disorders up to 1 January 2019. We summarized the milestones in the history of CBF assessment and reviewed the current evidence on the association between CBF and cognitive changes in normal aging, vascular cognitive impairment (VCI) and Alzheimer’s disease (AD). There is promising evidence regarding the utility of CBF studies in cognition research. Age-related CBF changes could be related to a progressive neuronal loss or diminished activity and synaptic density of neurons in the brain. While a similar cause or outcome theory applies to VCI and AD, it is possible that CBF reduction might precede cognitive decline. Despite the diversity of CBF research findings, its measurement could help early detection of cognitive disorders and also understanding their underlying etiology.
- Subjects :
- Aging
neurovascular coupling
Disease
Normal aging
030218 nuclear medicine & medical imaging
03 medical and health sciences
Cognition
0302 clinical medicine
Alzheimer Disease
Cognitive Changes
Humans
Medicine
Cognitive Dysfunction
Radiology, Nuclear Medicine and imaging
Cognitive decline
Review Articles
functional imaging
business.industry
General Medicine
Functional imaging
nervous system
Cerebral blood flow
Cerebrovascular Circulation
cognitive disorders
cardiovascular system
Etiology
neuronal loss
Neurology (clinical)
Cognition Disorders
business
Neuroscience
030217 neurology & neurosurgery
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 23851996 and 19714009
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- The Neuroradiology Journal
- Accession number :
- edsair.doi.dedup.....aa84ac0b9c99e32d4e2cf7f8436dc270