Back to Search
Start Over
Resection margin clearance in pancreatic cancer after implementation of the Leeds Pathology Protocol (LEEPP): Clinically relevant or just academic?
- Source :
- Zeitschrift für Gastroenterologie. 51
- Publication Year :
- 2013
- Publisher :
- Georg Thieme Verlag KG, 2013.
-
Abstract
- The aim of this study was to assess the overall survival (OS) after R0/R1 resections in patients with pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head after implementation of a standardized histopathologic protocol (Leeds Pathology Protocol, LEEPP). One hundred and twenty-five patients underwent surgical resection because of PDAC of the pancreatic head. Patients were histopathologically examined according to a standardized protocol. Their oncologic outcome and clinicopathologic data were compared with those of a patient group before implementation of the LEEPP (n = 116). The R1 rate increased significantly from 13 to 52 %. There was no significant difference in OS between R0 and R1 resections. The median OS in patients with a tumor clearance of less than 2 mm from the resection margin was 15.1 months (12.1–18.1 months) versus 22.2 months (7.8–36.7 months) (P = 0.046). Multivariate analysis revealed a margin clearance or 2 mm and more as an independent prognosticator for OS. With applying the LEEPP, there was still no significant correlation between the R-status and OS in patients with PDAC. However, since a margin clearance of 2 mm or more is a predictive factor for OS, the R1 definition might have to be adapted in PDAC.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Neoplasm, Residual
Multivariate analysis
Pancreatic ductal adenocarcinoma
Pancreaticoduodenectomy
Pancreatic cancer
Humans
Medicine
Prospective Studies
Aged
Aged, 80 and over
Protocol (science)
business.industry
Gastroenterology
Middle Aged
Vascular surgery
medicine.disease
Surgery
Cardiac surgery
Pancreatic Neoplasms
Survival Rate
Cardiothoracic surgery
Multivariate Analysis
Resection margin
Female
business
Carcinoma, Pancreatic Ductal
Abdominal surgery
Subjects
Details
- ISSN :
- 14397803 and 00442771
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Zeitschrift für Gastroenterologie
- Accession number :
- edsair.doi.dedup.....aa81b54825d7038e4d2e4c3f669973f6