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Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma
- Source :
- Gastroenterology Research and Practice, Gastroenterology Research and Practice, Vol 2018 (2018)
- Publication Year :
- 2018
-
Abstract
- Aim. Child-Pugh (CP) grade has been used to assess liver function and postoperative outcomes in biliary tract neoplasms. The aim of this study was to preliminarily explore the prognostic significance of an alternative model of liver function, called albumin-bilirubin (ALBI) grade, in patients with extrahepatic cholangiocarcinoma (EHC). Methods. A total of 109 advanced EHC patients, who received percutaneous transhepatic biliary stenting combined with iodine-125 seed implantation from January 2012 to April 2017 in our department, were enrolled. Preoperative clinical data were collected to calculate the CP and ALBI grades. The performance of ALBI score in predicting postoperative death was compared with that of CP score by using the receiver operating characteristic (ROC) curve. Kaplan-Meier analysis and Cox regression model were performed for overall survival (OS) analysis. Results. The median survival time of our cohort was 12 months, and the 1-year and 2-year survival rates were 56.9% and 12.8%, respectively. The area under the ROC curve of ALBI score for predicting death was significantly greater than the CP score (0.751, 95% CI: 0.641–0.861, P<0.001 vs. 0.688, 95% CI: 0.567–0.809, P<0.001). The univariate analysis revealed that the factors related to overall survival of EHC were carbohydrate antigen 19-9, total bilirubin, albumin, ALBI grade, and CP score. In multivariate analysis, ALBI grade (HR = 1.65, 95% CI: 1.04–2.61, P=0.032), but not CP score, was identified as an independent prognostic model. Conclusion. We demonstrated that the ALBI grade could be used as a predictor of survival in unresectable EHC patients.
- Subjects :
- medicine.medical_specialty
Multivariate analysis
Percutaneous
Article Subject
Bilirubin
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
lcsh:RC799-869
Univariate analysis
Hepatology
Receiver operating characteristic
business.industry
Proportional hazards model
chemistry
030220 oncology & carcinogenesis
Cohort
030211 gastroenterology & hepatology
lcsh:Diseases of the digestive system. Gastroenterology
Liver function
business
Research Article
Subjects
Details
- ISSN :
- 16876121
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Gastroenterology research and practice
- Accession number :
- edsair.doi.dedup.....aa7cbbb496e02571a04217557d2fdaaf