Back to Search
Start Over
Impact of Biohybrid Magnetite Nanoparticles and Moroccan Propolis on Adherence of Methicillin Resistant Strains of Staphylococcus aureus
- Source :
- Molecules, Vol 21, Iss 9, p 1208 (2016), Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Molecules; Volume 21; Issue 9; Pages: 1208, Molecules
- Publication Year :
- 2016
- Publisher :
- MDPI AG, 2016.
-
Abstract
- Biofilm bacteria are more resistant to antibiotics than planktonic cells. Propolis possesses antimicrobial activity. Generally, nanoparticles containing heavy metals possess antimicrobial and antibiofilm properties. In this study, the ability of adherence of Methicillin Resistant Strains of Staphylococcus aureus (MRSA) to catheters treated with magnetite nanoparticles (MNPs), produced by three methods and functionalized with oleic acid and a hydro-alcoholic extract of propolis from Morocco, was evaluated. The chemical composition of propolis was established by gas chromatography mass spectrometry (GC-MS), and the fabricated nanostructures characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Mossbauer spectroscopy and Fourrier transform infrared spectroscopy (FTIR). The capacity for impairing biofilm formation was dependent on the strain, as well as on the mode of production of MNPs. The co-precipitation method of MNPs fabrication using Fe(3+) and Na₂SO₃ solution and functionalized with oleic acid and propolis was the most effective in the impairment of adherence of all MRSA strains to catheters (p < 0.001). The adherence of the strain MRSA16 was also significantly lower (p < 0.001) when the catheters were treated with the hybrid MNPs with oleic acid produced by a hydrothermal method. The anti-MRSA observed can be attributed to the presence of benzyl caffeate, pinocembrin, galangin, and isocupressic acid in propolis extract, along with MNPs. However, for MRSA16, the impairment of its adherence on catheters may only be attributed to the hybrid MNPs with oleic acid, since very small amount, if any at all of propolis compounds were added to the MNPs. info:eu-repo/semantics/publishedVersion
- Subjects :
- 0301 basic medicine
hydrothermal
Pharmaceutical Science
02 engineering and technology
medicine.disease_cause
Bacterial Adhesion
Analytical Chemistry
chemistry.chemical_compound
Drug Discovery
co-precipitation
functionalization
propolis
flavonoids
diterpenes
Magnetite Nanoparticles
Pinocembrin
biology
Chemistry
021001 nanoscience & nanotechnology
Antimicrobial
Galangin
Morocco
Chemistry (miscellaneous)
Staphylococcus aureus
Molecular Medicine
Diterpenes
0210 nano-technology
Methicillin-Resistant Staphylococcus aureus
Article
Propolis
Microbiology
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
medicine
Physical and Theoretical Chemistry
Functionalization
Flavonoids
Organic Chemistry
Biofilm
biology.organism_classification
Hydrothermal
Oleic acid
030104 developmental biology
Biofilms
Co-precipitation
Bacteria
Nuclear chemistry
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....aa68a16ae1b0e1c531dce832570c7bd5