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Differences in Functional Brain Networks Between Subjective Cognitive Decline with and without Worry Groups: A Graph Theory Study from SILCODE
- Source :
- Journal of Alzheimer's disease 84(3), 1279-1289 (2021). doi:10.3233/JAD-215156
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Evidence suggests that subjective cognitive decline (SCD) individuals with worry have a higher risk of cognitive decline. However, how SCD-related worry influences the functional brain network is still unknown. Objective: In this study, we aimed to explore the differences in functional brain networks between SCD subjects with and without worry. Methods: A total of 228 participants were enrolled from the Sino Longitudinal Study on Cognitive Decline (SILCODE), including 39 normal control (NC) subjects, 117 SCD subjects with worry, and 72 SCD subjects without worry. All subjects completed neuropsychological assessments, APOE genotyping, and resting-state functional magnetic resonance imaging (rs-fMRI). Graph theory was applied for functional brain network analysis based on both the whole brain and default mode network (DMN). Parameters including the clustering coefficient, shortest path length, local efficiency, and global efficiency were calculated. Two-sample T-tests and chi-square tests were used to analyze differences between two groups. In addition, a false discovery rate-corrected post hoc test was applied. Results: Our analysis showed that compared to the SCD without worry group, SCD with worry group had significantly increased functional connectivity and shortest path length (p = 0.002) and a decreased clustering coefficient (p = 0.013), global efficiency (p = 0.001), and local efficiency (p
- Subjects :
- Male
Longitudinal study
China
media_common.quotation_subject
graph theory
Anxiety
Neuropsychological Tests
physiopathology [Brain]
Functional brain
Functional connectivity
Post-hoc analysis
medicine
worry
Humans
Cognitive Dysfunction
ddc:610
Longitudinal Studies
Cognitive decline
Default mode network
media_common
Aged
medicine.diagnostic_test
business.industry
General Neuroscience
Neuropsychology
Brain
Default Mode Network
General Medicine
Magnetic Resonance Imaging
Psychiatry and Mental health
Clinical Psychology
statistics & numerical data [Neuropsychological Tests]
psychology [Anxiety]
functional MRI
Female
psychology [Cognitive Dysfunction]
Geriatrics and Gerontology
Worry
subjective cognitive decline
Functional magnetic resonance imaging
business
Clinical psychology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease 84(3), 1279-1289 (2021). doi:10.3233/JAD-215156
- Accession number :
- edsair.doi.dedup.....aa67978003ba09fcffae03151b8c8e41