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Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs
- Source :
- Journal of Gastroenterology. 56(5):422-433
- Publication Year :
- 2021
- Publisher :
- Springer, 2021.
-
Abstract
- Eosinophilic esophagitis (EoE) is considered to be an immunoglobulin E (IgE)-mediated allergic disorder. Our goal was to examine IgE-mediated allergic sensitization patterns in patients with esophageal eosinophilia (EE). We enrolled subjects with EE who underwent evaluation with a diagnostic panel to document multiple allergen-specific IgEs. Statistically significant groups were identified by cluster analysis. We also defined allergens based on their characteristics including outdoor, indoor, plant, and animal allergens. We classified patients with EE into 3 distinct groups, including cluster 1 (n = 62) who were minimally sensitized to most allergens except pollen and house dust, cluster 2 (n = 30) who were hypersensitized to outdoor and plant allergens, and cluster 3 (n = 15) who were hypersensitized to most allergens, most notably to indoor and animal allergens. Dysphagia reported among those in clusters 1, 2, and 3 at 35.5%, 46.7%, and 73.3%, respectively, (p = 0.028) and EoE endoscopic reference scores (EREFS) at 3.0, 6.0, and 8.0, respectively, (p
- Subjects :
- Adult
Male
medicine.medical_specialty
アレルゲン
medicine.disease_cause
Immunoglobulin E
Gastroenterology
Statistics, Nonparametric
Allergic sensitization
03 medical and health sciences
0302 clinical medicine
Allergen
Japan
Internal medicine
medicine
Humans
Eosinophilia
免疫グロブリンE
Eosinophilic esophagitis
Sensitization
Diagnostic panel
Retrospective Studies
biology
business.industry
Sensitization patterns
Middle Aged
respiratory system
Allergens
medicine.disease
Dysphagia
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
好酸球性食道炎
biology.protein
Female
Immunization
030211 gastroenterology & hepatology
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 14355922
- Volume :
- 56
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....aa6483e37f9ea554d133ce2d9e2918bd