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Increased prevalence of obstructive sleep apnoea in patients with Charcot-Marie-Tooth disease: a case control study
- Source :
- Journal of neurology, neurosurgery, and psychiatry. 79(7)
- Publication Year :
- 2008
-
Abstract
- Obstructive sleep apnoea (OSA) has previously been described in a large family suffering from Charcot-Marie-Tooth disease type 1 (CMT1). In the present study, we used a case control design to establish whether this suggested link between OSA and CMT1 may also be found when studying genetically non-related patients. 12 patients with CMT1 and 24 control patients matched for age, sex and body mass index (BMI) were included in the study. Neurological disability was graded with a previously established 6 point score. All patients underwent overnight polysomnography. The mean apnoea-hypopnoea index (AHI) of patients with CMT1 was 10.5 (16.3) which was significantly higher than that of the control group (1.5 (1.3)). Five out of 12 patients with CMT1 had an AHI > or =10/h compared with 1 of 24 control patients (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Neuromuscular disease
Polysomnography
Body Mass Index
Central nervous system disease
Cohort Studies
stomatognathic system
Charcot-Marie-Tooth Disease
Risk Factors
Internal medicine
medicine
Humans
Sleep Apnea, Obstructive
medicine.diagnostic_test
business.industry
Respiratory disease
Case-control study
Age Factors
Sleep apnea
Middle Aged
medicine.disease
nervous system diseases
respiratory tract diseases
Surgery
Psychiatry and Mental health
Case-Control Studies
Female
Neurology (clinical)
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 1468330X
- Volume :
- 79
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Accession number :
- edsair.doi.dedup.....aa6205a904eaf807be1e4f6d6a060a9e