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Characterization of the Neuroendocrine Tumor Immune Microenvironment
- Source :
- Pancreas. 47:1123-1129
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- OBJECTIVES: The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic neuroendocrine tumors. METHODS: We assessed expression of PDCD1 (PD-1), CD274 (PD-L1) and PDCD1LG2 (PD-L2 ) in archival tissue from 64 small intestine (SINET) and 31 pancreatic neuroendocrine tumors (pNET). We additionally assessed T cell infiltrates, categorizing T cell subsets based on expression of the T cell markers CD3, CD8, CD45RO (PTPRC) or FOXP3. Finally, we explored associations between immune checkpoint marker expression, lymphocytic infiltrate and tumor mutational profiles. RESULTS: Expression of PD-1 or PD-L1 in small intestine or pancreatic NET was rare, while expression of PD-L2 was common in both NET subtypes. T-cell infiltrates were more abundant in pNET than in SINET. We found no clear associations between immune checkpoint marker expression, immune infiltrates, and specific mutational profile within each tumor type. CONCLUSIONS: Our findings provide an initial assessment of the immune environment of well-differentiated neuroendocrine tumors. Further studies to define the immunologic differences between pNET and SINET, as well as the role of PD-L2 in these tumors, are warranted.
- Subjects :
- Adult
Male
0301 basic medicine
T-Lymphocytes
animal diseases
Endocrinology, Diabetes and Metabolism
Immune microenvironment
Programmed Cell Death 1 Receptor
chemical and pharmacologic phenomena
Neuroendocrine tumors
Article
B7-H1 Antigen
Lymphocytic Infiltrate
03 medical and health sciences
0302 clinical medicine
Endocrinology
Immune system
PD-L1
Intestinal Neoplasms
Intestine, Small
Tumor Microenvironment
Internal Medicine
medicine
Humans
Aged
Aged, 80 and over
Tumor microenvironment
Hepatology
biology
Middle Aged
biochemical phenomena, metabolism, and nutrition
Programmed Cell Death 1 Ligand 2 Protein
medicine.disease
Small intestine
Immune checkpoint
Pancreatic Neoplasms
Neuroendocrine Tumors
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Cancer research
bacteria
Female
Subjects
Details
- ISSN :
- 15364828 and 08853177
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....aa610ff7b6b24acddebe661cc8472311