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Endotoxinemia and benzodiazepine-like substances in compensated cirrhotic patients: a randomized study comparing the effect of rifaximine alone and in association with a symbiotic preparation
- Source :
- Hepatology research : the official journal of the Japan Society of Hepatology. 28(3)
- Publication Year :
- 2003
-
Abstract
- Aim: The aim of the present investigation was to test study benzodiazepines (BZDs) profile in patients with viral cirrhosis under different combinations of rifaximine and of a novel symbiotic. Methods: Our study groups consisted of 30 patients with a confirmed diagnosis of HCV-related Child B liver cirrhosis. Patients were randomly allocated into three groups: rifaximine 400mg t.i.d. for 2 weeks; (B) SCM-III (Lactobacillus acidophilus, Lactobacillus helveticus and Bifidobacteria in a ion- and vitamin-enriched medium, Named srl, Italy) 10ml t.i.d. for 2 weeks; (C) rifaximine 400mg t.i.d. for 1 week followed by SCM-III 10ml t.i.d. for 5 weeks. At weekly interval, blood samples were withdrawn to test BZD-like substances, ammonia and endotoxin. Results: Rifaximine treatment brought about a significant early drop of BZDs ( [Formula: see text] versus pre-treatment and versus control) till fourth week of observation when a gradual increase took place with return to pre-treatment values at the sixth week. Symbiotic treatment was comparably effective while given to patients but significantly elevated BZDs level were noted starting from the third week. Similar phenomena were noted for endotoxin and ammonia although symbiotic seemed more effective against endotoxin and rifaximine against ammonia increase. However, the sequential treatment rifaximine-symbiotic brought about a sustained normalization of BZDs, ammonia and endotoxin throughout the 6-week study. Conclusion: The present pilot study suggests that a rifaximine-symbiotic regimen could be an effective tool in compensated liver cirrhosis to limit some triggering factors of hepatic encephalopathy while being amenable to long-term use and devoid of significant side effects.
- Subjects :
- Benzodiazepine
medicine.medical_specialty
Lactobacillus helveticus
Cirrhosis
Hepatology
biology
business.industry
medicine.drug_class
biology.organism_classification
medicine.disease
Gastroenterology
Surgery
law.invention
Regimen
Infectious Diseases
Lactobacillus acidophilus
Randomized controlled trial
Rifaximine
law
Internal medicine
Medicine
business
Hepatic encephalopathy
Subjects
Details
- ISSN :
- 13866346
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Hepatology research : the official journal of the Japan Society of Hepatology
- Accession number :
- edsair.doi.dedup.....aa5a15fae6e19056b8eac0ef19e2122d