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A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population
- Source :
- European psychiatry : the journal of the Association of European Psychiatrists. 26(8)
- Publication Year :
- 2011
-
Abstract
- Genetic aspects may influence the effect of early adverse events on psychological well being in adulthood. In particular, a common polymorphism within the serotonin transporter gene (5-HTTLPR short/long) has been associated to the risk for stress-induced psychopathology. In the present study we investigated the role of childhood traumas and 5-HTTLPR on measures of psychological resilience and depression in a sample of individuals at a high risk for psychological distress (763 male prisoners). The 5-HTTLPR genotype did not influence resilience and depressive severity. However, a significant interaction was observed between 5-HTTLPR and childhood traumas on both resilience and depressive severity. In particular, among subjects exposed to severe childhood trauma only, the long-allele was associated to lower resilience scores and increased current depressive severity as compared to short/short homozygous. Sex specific effects, difference in type and duration of stressors and the specific composition of the sample may explain discrepancy with many studies reporting the short-allele as a vulnerability factor for reactivity to stress. We here speculated that in males the long-allele may confer lower resilience and therefore higher vulnerability for depressive symptoms in subjects exposed to early stress and currently living in stressful environments.
- Subjects :
- Adult
Male
medicine.medical_specialty
media_common.quotation_subject
Population
Stress
Severity of Illness Index
Life Change Events
03 medical and health sciences
0302 clinical medicine
Risk Factors
stre
medicine
Genetics
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
Psychiatry
education
Adverse effect
Serotonin transporter
Depression (differential diagnoses)
media_common
Serotonin Plasma Membrane Transport Proteins
education.field_of_study
Depressive Disorder
Polymorphism, Genetic
biology
Psychopathology
Adult Survivors of Child Abuse
Stressor
Middle Aged
Resilience, Psychological
030227 psychiatry
Affective disorders
Psychiatry and Mental health
Psychological well-being
biology.protein
Gene-Environment Interaction
Psychological resilience
Psychology
Stress, Psychological
Clinical psychology
Subjects
Details
- ISSN :
- 17783585
- Volume :
- 26
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- European psychiatry : the journal of the Association of European Psychiatrists
- Accession number :
- edsair.doi.dedup.....aa3ae5f4649a3bb5466684f346f654e0