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Plasma Epinephrine Predicts Fasting Glucose in Centrally Obese African-American Women
- Publication Year :
- 2010
-
Abstract
- The high prevalence of diabetes in African-American (AA) women has been widely assumed to be related to the greater prevalence of obesity in this group. Catecholamine release acting on central adipose tissue has been proposed to be a contributing factor. The aim of this article was to examine the interaction of plasma catecholamines and central adiposity on fasting and nonfasting glucose levels in two separate samples. In both studies, the women were healthy, nondiabetic of similar age. In addition, both studies assessed plasma epinephrine (EPI) and norepinephrine (NOREPI) levels collected at three time points. In study 1, catecholamines were measured during a standardized laboratory mental stress task and in study 2, they were measured during the initial phase (10 min) of an intravenous glucose tolerance test (IVGTT). Results from both studies revealed significant effects of EPI on fasting glucose in the obese women. In study 1, mean EPI levels were significantly related to fasting glucose in AA women with high trunk fat (β = 0.60, P < 0.001). Because high BMI was associated with high trunk fat in women, we used BMI >30 as a proxy for high trunk fat (>32%) in study 2. In study 2, EPI response to the glucose bolus was a strong predictor of fasting glucose in AA women with BMI >30 (β = 0.75, P < 0.003). We conclude that the effect of central adiposity on fasting glucose may be moderated by plasma EPI. This suggests that adrenal medullary activity could play a role in the pathophysiology of type 2 diabetes.
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
Epinephrine
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Blood sugar
Type 2 diabetes
Article
Body Mass Index
Young Adult
Endocrinology
Internal medicine
Diabetes mellitus
Blood plasma
Glucose Intolerance
medicine
Humans
Glucose tolerance test
Nutrition and Dietetics
medicine.diagnostic_test
business.industry
Fasting
Glucose Tolerance Test
medicine.disease
Black or African American
Obesity, Abdominal
Catecholamine
Regression Analysis
Female
business
Body mass index
Stress, Psychological
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....aa3ae381fa105487a3d07570bdebd177