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Association of MCP‐1 promoter polymorphism with susceptibility to nasopharyngeal carcinoma
- Source :
- Journal of Cellular Biochemistry. 120:6661-6670
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Nasopharyngeal carcinoma (NPC) is prevalent among populations from southern China and is influenced by both genetic and environmental risk factors. The monocyte chemoattractant protein-1 (MCP-1), a member of cysteine-cysteine chemokine family, plays critical roles in cancers. A polymorphism within the MCP-1 promoter, rs1024611, has been shown to be significantly associated with the risk of several cancers. Our purpose was to assess the role of rs1024611 in NPC susceptibility. By polymerase chain reaction-restriction fragment length polymorphism method, we genotyped rs1024611 in 593 patients with NPC (cases) and 480 cancer-free subjects (controls) among Guangxi population from southern China. We observed that the G allele of rs1024611 was significantly associated with the increased risk of NPC in an additive model and dominant model, respectively (P = 0.018 and 0.010, odds ratio = 1.25 and 1.41, respectively). No appreciable variation of the effects was found across the subgroups stratified by age, sex, nationality, smoking and drinking status, and smoking level. In addition, significantly higher messenger RNA (mRNA) expression level of MCP-1 was observed in NPC tissues than that in normal nasopharyngeal tissues, and the G allele of rs1024611 was significantly associated with elevated mRNA expression level of MCP-1 in Epstein-Barr virus-transformed lymphocytes. In conclusion, our findings suggested that rs1024611 at the MCP-1 promoter may be a risk factor for NPC. Further studies with larger sample size are necessary to confirm these findings.
- Subjects :
- Male
0301 basic medicine
Chemokine
Population
Polymorphism, Single Nucleotide
Biochemistry
03 medical and health sciences
0302 clinical medicine
Biomarkers, Tumor
medicine
Genetic predisposition
Humans
Genetic Predisposition to Disease
Allele
Promoter Regions, Genetic
education
Molecular Biology
Chemokine CCL2
education.field_of_study
Messenger RNA
Nasopharyngeal Carcinoma
biology
Monocyte
Nasopharyngeal Neoplasms
Cell Biology
Odds ratio
DNA Methylation
Middle Aged
Prognosis
medicine.disease
Gene Expression Regulation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
Nasopharyngeal carcinoma
Case-Control Studies
030220 oncology & carcinogenesis
Immunology
biology.protein
Female
Follow-Up Studies
Subjects
Details
- ISSN :
- 10974644 and 07302312
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Biochemistry
- Accession number :
- edsair.doi.dedup.....aa36b4d9f950b2a1c1939eb159e80d63