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Dominant lethal mutation test in male mice exposed to 900MHz radiofrequency fields
- Source :
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 792:53-57
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Adult male ICR mice were exposed to continuous wave 900MHz radiofrequency fields (RF) at 1.6mW/cm(2) power intensity (whole body average specific absorption rate of 0.731W/kg) for 4 hour/day for 15 days. At the end of exposure, each mouse was caged with 3 mature virgin female mice for mating. After 7 days, each male mouse was transferred to a fresh cage and mated with a second batch of 3 females. This process was repeated for a total of 4 consecutive weeks. Sham exposed male mice and those subjected to an acute 2Gy γ-irradiation (GR) were handled similarly and used as un-exposed and positive controls, respectively. All females were sacrificed on the 18th day of gestation and presumptive mating and, the contents in their uteri were examined. The overall observations during the 4 weeks of mating indicated that the un-exposed female mice mated to RF-exposed male mice showed no significant differences in the percentage of pregnancies, total implants, live implants and dead implants when compared with those mated with sham-exposed mice. In contrast, female mice mated with GR-exposed males showed a consistent pattern of significant differences in the above indices in each and all 4 weeks of mating. Thus, the data indicated an absence of mutagenic potential of RF exposure in the germ cells of male mice.
- Subjects :
- Male
medicine.medical_specialty
Radio Waves
Health, Toxicology and Mutagenesis
Male mice
Biology
medicine.disease_cause
Andrology
Mice
Pregnancy
Dominant lethal
Internal medicine
Genetics
medicine
Animals
Mating
reproductive and urinary physiology
Genes, Dominant
Mice, Inbred ICR
Mutation
Body Weight
medicine.disease
Endocrinology
Gamma Rays
Paternal Exposure
Pregnancy, Animal
Gestation
Female
Cage
Icr mice
Mutagens
Subjects
Details
- ISSN :
- 13835718
- Volume :
- 792
- Database :
- OpenAIRE
- Journal :
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Accession number :
- edsair.doi.dedup.....aa3540cdae91f29373c9ee8049b523f9