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T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins
- Source :
- Frontiers in Immunology, 8(October), 1. Frontiers Media S.A., Frontiers in Immunology, Frontiers in Immunology, Vol 8 (2017)
- Publication Year :
- 2017
-
Abstract
- Failing immunological tolerance for critical self-antigens is the problem underlying most chronic inflammatory diseases of humans. Despite the success of novel immunosuppressive biological drugs, the so-called biologics, in the treatment of diseases such rheumatoid arthritis (RA) and type 1 diabetes, none of these approaches does lead to a permanent state of medicine free disease remission. Therefore, there is a need for therapies that restore physiological mechanisms of self-tolerance. Heat shock proteins (HSPs) have shown disease suppressive activities in many models of experimental autoimmune diseases through the induction of regulatory T cells (Tregs). Also in first clinical trials with HSP-based peptides in RA and diabetes, the induction of Tregs was noted. Due to their exceptionally high degree of evolutionary conservation, HSP protein sequences (peptides) are shared between the microbiota-associated bacterial species and the self-HSP in the tissues. Therefore, Treg mechanisms, such as those induced and maintained by gut mucosal tolerance for the microbiota, can play a role by targeting the more conserved HSP peptide sequences in the inflamed tissues. In addition, the stress upregulated presence of HSP in these tissues may well assist the targeting of the HSP induced Treg specifically to the sites of inflammation.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
rheumatoid arthritis
T cell
T regulatory cells
Immunology
Inflammation
Review
Disease
Biology
Conserved sequence
03 medical and health sciences
Downregulation and upregulation
Heat shock protein
medicine
Immunology and Allergy
inflammatory eye diseases
tolerance
medicine.disease
Tolerance induction
type 1
030104 developmental biology
medicine.anatomical_structure
Rheumatoid arthritis
diabetes mellitus
heat shock proteins
nflammatory eye diseases
medicine.symptom
Immunologic diseases. Allergy
lcsh:RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology, 8(October), 1. Frontiers Media S.A., Frontiers in Immunology, Frontiers in Immunology, Vol 8 (2017)
- Accession number :
- edsair.doi.dedup.....aa32a476fc8cd4f1638e8e4067aa6bbd