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Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants
- Source :
- Clinical Nutrition (Edinburgh, Scotland), Curtis, P J, Berends, L, van der Velpen, V, Jennings, A, Haag, L, Chandra, P, Kay, C D, Rimm, E B & Cassidy, A 2022, ' Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: results from a double blind, randomized controlled trial in metabolic syndrome participants ', Clinical Nutrition, vol. 41, no. 1, pp. 165-176 . https://doi.org/10.1016/j.clnu.2021.11.030
- Publication Year :
- 2021
-
Abstract
- Summary Background & aims Whilst the cardioprotective effects of blueberry intake have been shown in prospective studies and short-term randomized controlled trials (RCTs), it is unknown whether anthocyanin-rich blueberries can attenuate the postprandial, cardiometabolic dysfunction which follows energy-dense food intakes; especially in at-risk populations. We therefore examined whether adding blueberries to a high-fat/high-sugar meal affected the postprandial cardiometabolic response over 24 h. Methods A parallel, double-blind RCT (n = 45; age 63.4 ± 7.4 years; 64% male; BMI 31.4 ± 3.1 kg/m2) was conducted in participants with metabolic syndrome. After baseline assessments, an energy-dense drink (969 Kcals, 64.5 g fat, 84.5 g carbohydrate, 17.9 g protein) was consumed with either 26 g (freeze-dried) blueberries (equivalent to 1 cup/150 g fresh blueberries) or 26 g isocaloric matched placebo. Repeat blood samples (30, 60, 90, 120, 180, 360 min and 24 h), a 24 h urine collection and vascular measures (at 3, 6, and 24 h) were performed. Insulin and glucose, lipoprotein levels, endothelial function (flow mediated dilatation (FMD)), aortic and systemic arterial stiffness (pulse wave velocity (PWV), Augmentation Index (AIx) respectively), blood pressure (BP), and anthocyanin metabolism (serum and 24 h urine) were assessed. Results Blueberries favorably affected postprandial (0–24 h) concentrations of glucose (p
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
medicine.medical_treatment
Lipoproteins
Population
Blueberry Plants
Energy-dense meal challenge
Blood Pressure
Pulse Wave Analysis
Critical Care and Intensive Care Medicine
Diet, High-Fat
Anthocyanins
Randomized Control Trials
Vascular Stiffness
Double-Blind Method
Internal medicine
Blueberry anthocyanins
medicine
Humans
Insulin
education
Postprandial assessment
Pulse wave velocity
Meals
Aged
Metabolic Syndrome
Flavonoids
Meal
education.field_of_study
Nutrition and Dietetics
business.industry
Middle Aged
medicine.disease
Postprandial Period
Cardiovascular disease risk
Blood pressure
Postprandial
Endocrinology
Arterial stiffness
Female
Endothelium, Vascular
Metabolic syndrome
Diet, Carbohydrate Loading
business
Energy Intake
Subjects
Details
- ISSN :
- 15321983
- Volume :
- 41
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Accession number :
- edsair.doi.dedup.....aa1ef8e1076e284cdcfddca5b866e639
- Full Text :
- https://doi.org/10.1016/j.clnu.2021.11.030