Back to Search Start Over

Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants

Authors :
Eric B. Rimm
Aedin Cassidy
Vera van der Velpen
Laura Haag
Peter J. Curtis
Lindsey Berends
Preeti Chandra
Colin D. Kay
Amy Jennings
Source :
Clinical Nutrition (Edinburgh, Scotland), Curtis, P J, Berends, L, van der Velpen, V, Jennings, A, Haag, L, Chandra, P, Kay, C D, Rimm, E B & Cassidy, A 2022, ' Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: results from a double blind, randomized controlled trial in metabolic syndrome participants ', Clinical Nutrition, vol. 41, no. 1, pp. 165-176 . https://doi.org/10.1016/j.clnu.2021.11.030
Publication Year :
2021

Abstract

Summary Background & aims Whilst the cardioprotective effects of blueberry intake have been shown in prospective studies and short-term randomized controlled trials (RCTs), it is unknown whether anthocyanin-rich blueberries can attenuate the postprandial, cardiometabolic dysfunction which follows energy-dense food intakes; especially in at-risk populations. We therefore examined whether adding blueberries to a high-fat/high-sugar meal affected the postprandial cardiometabolic response over 24 h. Methods A parallel, double-blind RCT (n = 45; age 63.4 ± 7.4 years; 64% male; BMI 31.4 ± 3.1 kg/m2) was conducted in participants with metabolic syndrome. After baseline assessments, an energy-dense drink (969 Kcals, 64.5 g fat, 84.5 g carbohydrate, 17.9 g protein) was consumed with either 26 g (freeze-dried) blueberries (equivalent to 1 cup/150 g fresh blueberries) or 26 g isocaloric matched placebo. Repeat blood samples (30, 60, 90, 120, 180, 360 min and 24 h), a 24 h urine collection and vascular measures (at 3, 6, and 24 h) were performed. Insulin and glucose, lipoprotein levels, endothelial function (flow mediated dilatation (FMD)), aortic and systemic arterial stiffness (pulse wave velocity (PWV), Augmentation Index (AIx) respectively), blood pressure (BP), and anthocyanin metabolism (serum and 24 h urine) were assessed. Results Blueberries favorably affected postprandial (0–24 h) concentrations of glucose (p

Details

ISSN :
15321983
Volume :
41
Issue :
1
Database :
OpenAIRE
Journal :
Clinical nutrition (Edinburgh, Scotland)
Accession number :
edsair.doi.dedup.....aa1ef8e1076e284cdcfddca5b866e639
Full Text :
https://doi.org/10.1016/j.clnu.2021.11.030