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Isolation and characterization of the major equilibrium product of FK-520
- Source :
- The Journal of Antibiotics. 47:806-811
- Publication Year :
- 1994
- Publisher :
- Japan Antibiotics Research Association, 1994.
-
Abstract
- The existence of an isomeric form in equilibrium with the major component of FK-520 in polar solutions has been demonstrated. This minor component has been isolated in high yield and purity by a novel crystallization strategy and preparative HPLC. The equilibrium product was characterized by NMR and MS.
- Subjects :
- Pharmacology
Magnetic Resonance Spectroscopy
Chromatography
Chemistry
Component (thermodynamics)
Kinetics
Nuclear magnetic resonance spectroscopy
Mass spectrometry
Mass Spectrometry
Tacrolimus
Anti-Bacterial Agents
law.invention
Isomerism
law
Yield (chemistry)
Product (mathematics)
Drug Discovery
Polar
Spectrophotometry, Ultraviolet
Crystallization
Chromatography, High Pressure Liquid
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 18811469 and 00218820
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- The Journal of Antibiotics
- Accession number :
- edsair.doi.dedup.....aa1d98a4a4c04bf551a9784af029a28e
- Full Text :
- https://doi.org/10.7164/antibiotics.47.806