Back to Search
Start Over
Plant-based diets, insulin sensitivity and inflammation in elderly men with chronic kidney disease
- Source :
- Journal of Nephrology
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background In persons with CKD, adherence to plant-based diets is associated with lower risk of CKD progression and death, but underlying mechanisms are poorly characterized. We here explore associations between adherence to plant-based diets and measures of insulin sensitivity and inflammation in men with CKD stages 3–5. Methods Cross-sectional study including 418 men free from diabetes, aged 70–71 years and with cystatin-C estimated glomerular filtration rate (eGFR) 2 and not receiving kidney-specific dietetic advice. Information from 7-day food records was used to evaluate the adherence to a plant-based diet index (PBDi), which scores positively the intake of plant-foods and negatively animal-foods. Insulin sensitivity and glucose disposal rate were assessed with the gold-standard hyperinsulinemic euglycemic glucose clamp technique. Inflammation was evaluated by serum concentrations of C-reactive protein (CRP) and interleukin (IL)-6. Associations were explored through linear regression and restricted cubic splines. Results The majority of men had CKD stage 3a. Hypertension and cardiovascular disease were the most common comorbidities. The median PBDi was 38 (range 14–55). Across higher quintiles of PBDi (i.e. higher adherence), participants were less often smokers, consumed less alcohol, had lower BMI and higher eGFR (P for trend Conclusion In elderly men with non-dialysis CKD stages 3–5, adherence to a plant-based diet was associated with higher insulin sensitivity and lower inflammation, supporting a possible role of plant-based diets in the prevention of metabolic complications of CKD. Graphic abstract
- Subjects :
- Male
Nephrology
Protein-energy wasting
medicine.medical_specialty
Potasssium
Renal function
Disease
Vegetable
Lower risk
Gastroenterology
Internal medicine
Diabetes mellitus
Urologi och njurmedicin
Restriction
medicine
Animals
Humans
Urology and Nephrology
Renal Insufficiency, Chronic
Aged
Inflammation
business.industry
Diet, Vegetarian
Malnutrition
Klinisk medicin
Glucose clamp technique
medicine.disease
Cross-Sectional Studies
Fruit
Original Article
Insulin Resistance
Clinical Medicine
business
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 17246059 and 11218428
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....aa0fc7c50e2cd5213ecd195df3fbec80