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The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study

The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study

Authors :
Phan Thi Thanh Ha
Corinne N. Thompson
Le Bich Lien
Stephen Baker
Nguyen Trong Hieu
Tran Thi Ngoc Dung
Katherine L. Anders
Voong Vinh Phat
Le Thi Phuong Tu
Cameron P. Simmons
Nguyen Van Vinh Chau
Nguyen Thi Van Thuy
Nguyen Thi Hong Tham
Nguyen Minh Nguyet
Nguyen Thi Hong Van
Source :
International Journal of Infectious Diseases, International Journal of Infectious Diseases, Vol 35, Iss C, Pp 3-10 (2015)
Publication Year :
2015
Publisher :
Elsevier, 2015.

Abstract

Highlights • The diarrhoeal disease burden in a large, prospective infant cohort in Vietnam is defined. • Minimum incidence of clinic-based diarrhoea in infants: 271/1000 infant-years. • Rotavirus was most commonly identified, followed by norovirus and bacterial pathogens. • Frequent repeat infections with the same pathogen within 1 year. • Inclusion of rotavirus in the immunization schedule for Vietnam is warranted.<br />Summary Objectives Previous studies indicate a high burden of diarrhoeal disease in Vietnamese children, however longitudinal community-based data on burden and aetiology are limited. The findings from a large, prospective cohort study of diarrhoeal disease in infants in southern Vietnam are presented herein. Methods Infants were enrolled at birth in urban Ho Chi Minh City and a semi-rural district in southern Vietnam, and followed for 12 months (n = 6706). Diarrhoeal illness episodes were identified through clinic-based passive surveillance, hospital admissions, and self-reports. Results The minimum incidence of diarrhoeal illness in the first year of life was 271/1000 infant-years of observation for the whole cohort. Rotavirus was the most commonly detected pathogen (50% of positive samples), followed by norovirus (24%), Campylobacter (20%), Salmonella (18%), and Shigella (16%). Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella, or Campylobacter, and 13% of those with Salmonella infections. Conclusions The minimum incidence of diarrhoeal disease in infants in both urban and semi-rural settings in southern Vietnam was quantified prospectively. A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus. These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants.

Details

Language :
English
ISSN :
18783511 and 12019712
Volume :
35
Database :
OpenAIRE
Journal :
International Journal of Infectious Diseases
Accession number :
edsair.doi.dedup.....aa00a9799d07fd5c664c244e0667fba9