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A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
- Source :
- The Korean Journal of Internal Medicine
- Publication Year :
- 2014
- Publisher :
- Korean Association of Internal Medicine, 2014.
-
Abstract
- Background/Aims Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its prognostic role in patients with hepatocellular carcinoma (HCC) has not been investigated. Methods We collected HCC tissues from 83 HCC patients who underwent surgical resection for an immunohistochemical study of PDI. Overall survival (OS) was measured from the date of surgical resection until the date of death from any cause. Radiological progression was evaluated using the modified Response Evaluation Criteria in Solid Tumors in an independent radiological assessment. Results PDI expression was found to be increased in human HCC compared to adjacent nontumor tissues. Increased immunopositivity for PDI was associated with a high Edmondson-Steiner grade (p = 0.028). Univariate analysis of patients who had undergone surgical resection for HCC showed that tumor PDI upregulation is a significant risk factor for poor OS (p = 0.016; hazard ratio [HR], 1.980) and time to progression (TTP; p = 0.007; HR, 1.971). Multivariate analyses revealed that high PDI expression was an independent predictor of a shorter TTP (p = 0.015; HR, 1.865) and poor OS (p = 0.012; HR, 2.069). Conclusions Upregulated PDI expression is associated with aggressive clinicopathological features of HCC; thus, PDI might serve as an independent prognostic factor and a potential therapeutic target for HCC patients.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Prognostic factor
Carcinoma, Hepatocellular
Protein Disulfide-Isomerases
Kaplan-Meier Estimate
Biomarkers, Tumor
Carcinoma
medicine
Humans
In patient
Protein disulfide-isomerase
Retrospective Studies
business.industry
Endoplasmic reticulum
Liver Neoplasms
Middle Aged
Prognosis
medicine.disease
digestive system diseases
Hepatocellular carcinoma
Protein disulfide isomerases
Cancer cell
Endoplasmic reticulum stress
Cancer research
Original Article
Female
business
Subjects
Details
- ISSN :
- 20056648 and 12263303
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The Korean Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....a9fd9811043055b6748fec585a97645a