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Morphological effects of octreotide on growth hormone-producing pituitary adenomas
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 79:113-118
- Publication Year :
- 1994
- Publisher :
- The Endocrine Society, 1994.
-
Abstract
- The SRIH analog octreotide is a potent GH-inhibiting agent that has been used to effectively treat patients with acromegaly. To investigate the morphological changes induced by octreotide on GH-producing pituitary tumors, we examined 86 adenomas from acromegalic patients who participated in a multicenter study. GH- producing pituitary adenomas removed from 43 patients treated preoperatively with octreotide for 4 months were compared to those obtained from 43 untreated acromegalic patients. Tissue samples were studied by histology, immunohistochemistry, and transmission electron microscopy as well as light microscopic and ultrastructural morphometry. The morphological appearance of some tumors was unaltered by octreotide treatment. Necrotic changes were not apparent in any. Acidophilia and GH immunoreactivity were more pronounced in the octreotide-treated tumors. Perivascular and interstitial fibrosis was more prevalent in the octreotide group (72% vs. 42%). An increase in hormone granularity was obvious in 4 of 15 densely granulated and 2 of 9 sparsely granulated (SG) tumors from treated patients. A decrease in cell size was conspicuous in 4 of 15 densely granulated and 2 of 10 SG adenomas. There was a slight downward trend in the cell and cytoplasmic size in all treated tumors and a slight upward trend in secretory granule size in treated SG adenomas. Only 2 of 9 SG adenomas in the octreotide group, however, demonstrated a statistically significant reduction in cell and cytoplasmic size. There was no statistically significant change in the size of nuclei, secretory granules, or lysosomes between the 2 groups. Decreased cell size and increased granularity were not linked, however. We conclude that there are no striking morphological alterations in GH pituitary adenomas that can be consistently associated with octreotide treatment.
- Subjects :
- Adenoma
Cytoplasm
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Octreotide
Pituitary neoplasm
Biology
Cytoplasmic Granules
Biochemistry
Necrosis
Endocrinology
Pituitary adenoma
Internal medicine
Acromegaly
medicine
Humans
Pituitary Neoplasms
Cell Nucleus
Biochemistry (medical)
Pituitary tumors
Histology
medicine.disease
Immunohistochemistry
Microscopy, Electron
Somatostatin
Growth Hormone
medicine.drug
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....a9f71a6907a94b3737426d9ef098038a