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Propranolol pharmacokinetics in infants treated for Infantile Hemangiomas requiring systemic therapy: Modeling and dosing regimen recommendations
- Source :
- Pharmacology Research & Perspectives
- Publication Year :
- 2017
-
Abstract
- Propranolol has become the first choice therapy for complicated Infantile Hemangiomas (IH). The pharmacokinetics of propranolol were evaluated after repeated oral administration of a new pediatric solution of propranolol at 3 mg kg−1 day−1 given twice daily (BID) in infants (77‐243 days) with IH. A population model was built to describe the pharmacokinetics of propranolol in infants and to simulate different dosing regimens. One hundred and sixty‐seven plasma concentrations from 22 infants were used in the population analysis. Weight effect was tested on apparent clearance and volume of distribution. Monte‐Carlo simulations were performed for 4 dosing regimens: BID dosing with irregular or strict 12‐hour intervals and 2 different 3 time daily dosing (TID) regimens. The best model was a one‐compartment model with first‐order absorption and elimination rates. The weight affected the clearance but not the volume. Typical oral clearance was estimated at 3.06 L hour−1 kg−1 (95% CI: 1.14‐8.61 L hour−1 kg−1), close to adult clearance data. When regular BID dosing was compared to TID or irregular BID regimens, simulated median Cmin and Cmax were
- Subjects :
- Male
Population
Adrenergic beta-Antagonists
Cmax
Administration, Oral
Propranolol
030226 pharmacology & pharmacy
Drug Administration Schedule
03 medical and health sciences
Cmin
0302 clinical medicine
Pharmacokinetics
Medicine
Humans
Drug Dosage Calculations
Dosing
General Pharmacology, Toxicology and Pharmaceutics
education
Volume of distribution
education.field_of_study
business.industry
Body Weight
Pharmacokinetic Population analysis Modeling and Simulation Dermatology Pediatrics
Infant
Original Articles
Models, Theoretical
Regimen
Neurology
030220 oncology & carcinogenesis
Anesthesia
Practice Guidelines as Topic
Female
Original Article
business
Hemangioma
Monte Carlo Method
medicine.drug
Subjects
Details
- ISSN :
- 20521707
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pharmacology researchperspectives
- Accession number :
- edsair.doi.dedup.....a9dd34951cabb6c0edb319da8d4b7ca3